Prognostic risk factors of colorectal cancer patients with stage pT4bN0M0
Journal Title: Chinese Journal of Clinical Research - Year 2024, Vol 37, Issue 3
Abstract
Objective To analyze the prognostic characteristics of different invasion sites and the risk factors affecting overall prognosis, in patients with pT4b stage colorectal cancer who underwent radical resection and showed no lymph node metastasis （N0） by pathology. Methods The clinical and pathological data of colorectal cancer patients received surgical resection in China National Petroleum Corporation Central Hospital from 2017-01-01 to 2021-12-21 were calculated and followed up to 2022-12-31. The time of operation, the time of local recurrence or distant metastasis and the time of death were recorded. Risk factor analysis was grouped based on whether there was disease progression during follow-up. Prognosis of different groups was compared and logistic binary regression was used to screen for meaningful risk factors. Results Survival analysis showed that the disease-free survival (DFS) of patients with tumor invasion of abdominal wall or omentum was (22.2±3.2) months, DFS of tumor invasion of stomach or intestine was (28.3±5.6) months, DFS of tumor invasion of uterus or adnexal was (35.7±2.6) months, and DFS of tumor invasion of the bladder or ureteral was (30.1±3.4) months, Log-rank P=0.001 among groups. Multivariate analysis showed that the right colon (OR=6.829, 95%CI:1.603-29.093, P=0.009), tumor invasion of abdominal wall, omentum (OR=6.198, 95%CI:1.231-31.210, P=0.027), tumor maximum diameter (OR=0.565, 95%CI:0.365-0.874, P=0.010) were independent factors affecting the progression of colorectal cancer. Conclusion Among colorectal cancer patients with pathological staging pT4bN0M0, patients with tumor invasion of the uterus and appendix have the best prognosis, while patients with invasion of the abdominal wall and omentum have the worst prognosis. Patients with tumors located in the right colon and invading the abdominal wall, omentum, or smaller tumor lesions are more likely to experience regional recurrence or distant metastasis after surgery.
Authors and Affiliations
DONG Jiuxing, ZHAO Jia, WU Zhenming, LIU Jun, WANG Baoxin, SU Yu, QI Xiuheng
Keywords
Related Articles
- EP ID EP734513
- DOI 10.13429/j.cnki.cjcr.2024.03.018
- Views 30
- Downloads 0
Improvement of lumbar spine function in patients with lumbar spinal stenosis by spinal endoscopic bilateral decompression of the spinal canal with unilateral interlaminar approach
<b>Objective</b> To analyze the effect of spinal endoscopic unilateral interlaminar approach with bilateral decompression of the spinal canal in the improvement of lumbar spine function in patients with lumbar spinal st...
Animal experimental study of a new aortic arch fenestrated stent graft
Objective To evaluate the safety and efficacy of a novel aortic arch fenestrated membrane-covered stent graft implanted in situ in large animals after long-term maintenance. Methods Three healthy male Large White pigs (n...
Efficacy and safety of filiform needle combined with modified Zilan decoction for treatment of verruca plana among adolescents
Objective To evaluate the clinical efficacy and safety of filiform needles combined with modified Zilan decoction in treating verruca plana in adolescents. Methods A total of 120 adolescents with verruca plana treated at...
Mechanism of human leukocyte antigen-G inhibiting T cell immune function in triple-negative breast cancer
"<b>Objective</b>To investigate the mechanism of human leukocyte antigen-G (HLA-G) expression and T cells activation in triple-negative breast cancer(TNBC) cells to exert immunosuppressive function. <b>Methods</b> From...
Research progress on the mechanism of action of gut microbiota on hepatocellular carcinoma
Hepatocellular carcinoma (HCC) has a high incidence rate among the malignant tumors reported in the world, and its incidence rate and mortality continue to rise. In recent years, researches have shown that the gut microb...