PROGNOSTIC ROLE OF HUMAN PAPILLOMA VIRUS IN ORAL SQUAMOUS CELL CARCINOMA: A REVIEW
Journal Title: World Journal of Pharmaceutical and Medical Research - Year 2017, Vol 3, Issue 10
Abstract
Aim & background: In spite of increase in the incidence of oral squamous cell carcinoma, there are not serious achievements gained in related treatment modalities and survival rates. Hence, through identifying the etiologic factors and the prognostic parameters, it is hoped that it would be possible to cure the lesions and reduce patients’ suffering and ailments. Human Papilloma Virus (HPV) might be one of the most important prognostic factors in oral cavity cancers. This study is an attempt to investigate & review of HPV prognostic role in oral squamous cell carcinoma. Methods & Materials: The investigated articles have been collected and studied meticulously using the data bases of PubMed, Medline, Scopus and Google Scholar through keywords of HPV, prognosis, survival rate, clinical outcome, oral cancer and OSCC during years of 2000 to 2015. Results: After scrutinizing and considering 23 articles, it was clarified that HPV-positive tumors can be treated easier. It can be related to some reasons such as more sensitiveness to therapies including chemotherapy and chemo radiation therapy .Furthermore, according to 12 articles, it was concluded that patients with HPV-positive tumors had higher survival rates compared with the HPV-negative ones, HPV-positive characteristic can be a significant prognostic factor. Conclusion: OSCC Patients presenting with HPV, have better prognosis and therapeutic response compared to those HPV-negative patients.
Authors and Affiliations
Dr. Sareh Farhadi
Keywords
Related Articles
- EP ID EP657832
- DOI -
- Views 167
- Downloads 0
ANTIDIABETIC ACTIVITY OF ROOT OF TERMINALIA CHEBULA ON ALLOXAN INDUCED DIABETIC RAT
The aim of this study was to investigate the Antidiabetic and antihyperlipidemic activities of aqueous and ethanol extracts of roots of Terminalia Chebula in alloxan (ALX) induced diabetic rats. Diabetes was confirmed af...
A REVIEW ON IMPORTANCE AND PHARMACOLOGICAL APPLICATIONS OF FLAVONOIDS
Flavonoids, a class of plant secondary metabolites having a polyphenolic structure, are found in fruits, vegetables, grains, bark, roots, stems, flowers, tea, and wine. They have miscellaneous favorable biochemical and a...
PARACETAMOL ALLERGY: A CASE REPORT
Adverse reactions to medications prescribed or administered in dental practice can be worring. Others, such as allergic and pseudoallergic reactions, are generally unpredictable and unrelated to normal drug action. Parac...
A CRITICAL REVIEW OF PARADA (MERCURY) AND ITS TOXICITY
In Ayurveda, ousadhi comprises of three categories of ingredients viz, 1-herbal origin, 2- animal origin, 3-metal origin to attain the happy and healthy life. Herbal products were extensively used in the classic age in a...
FLYING BIRD SIGN OR EAGLE SIGN IN PNEUMOPERITONEUM
Pneumoperitoneum is a condition in which air in the peritoneum. The causes of pneumoperitoneum are bowel perforation, postoperative, infection with gas forming organism, Tubal insufflation test. The amount of air require...