Prognostic significance of neutrophil/lymphocyte ratio, platelet/lymphocyte ratio and mean platelet volume in the early stage mycosis fungoides
Journal Title: Dokuz Eylul Universitesi Tip Fakultesi Dergisi - Year 2019, Vol 33, Issue 2
Abstract
Objective: Mycosis Fungoides (MF) is the most common lymphoma among the primary cutaneous T-cell lymphomas. Although the prognosis is excellent in many patients diagnosed in the early stages, rapid transition to advanced stages may be seen in some patients. Recently, the neutrophil/lymphocyte ratio (NLR), platelet/lymphocyte ratio (PLR) and mean platelet volume (MPV) have been used as prognostic markers in lymphomas; however, there is no existing data in literature in patients with MF. Material and Method: The data of patients diagnosed with early stage MF having at least a 5-year follow up in the Skin and Venereal Diseases Department of Dokuz Eylul University Faculty of Medicine were retrospectively reviewed. Results: Transition to the advanced stages of the disease were observed in 15 (22.4%) of the 67 cases included in the study. The involvement ≥10% of the body surface area, presence of lymphopenia, and increased NLR (>2.60) and PLR (>138.3) were associated with poor prognosis, and NLR was found to be an independent prognostic marker. Conclusion: NLR and PLR may prove to be a simple and low cost screening method to identify high-risk patients in early stages of MF.
Authors and Affiliations
Özlem Özbağçıvan
Keywords
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- EP ID EP637874
- DOI 10.5505/deutfd.2019.55706
- Views 61
- Downloads 0
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