Prognostic Value of Percentage of Positive to Total Excised Axillary Lymph Nodes in Egypt with Triple Negative Breast Cancer: Multiple-Centers Experience
Journal Title: International Journal of Life Science - Year 2018, Vol 6, Issue 3
Abstract
Background: The total number of axillary lymph nodes [LNs] is the most important prognostic factor in breast cancer. Over long times, different studies indicated that the lymph node ratio [LNR] might predict outcome better than the number of positive LNs. The aim of this retrospective study was to evaluate prognostic value of the lymph node ratio [LNR] in triple negative breast cancer [TNBC]. Materials and Methods: sixety patients with triple negative breast cancer [TNBC] at Zagazig University Hospitals and Fakous Cancer Center were included. We analyzed the impact lymph node ratio [LNR] on the disease free survival [DFS] and overall survival [OS] [calculated by Kaplan–Meier method]. Results: our results showed that the optimal cut off value of LNR value was 0.65, and the optimal cut off value of PLN. The Kaplan–Meier survival analysis showed the higher value of Mean disease free survival among all patients was 33.21 months and 3 year DFS was 50.6%. Disease free survival was significantly longer in those with LNR ≤ 0.65 than those with LNR > 0.65 [Mean: 33.34 months versus 27.46 months; 3year DFS 56.4% versus 36.9% respectively]. Mean overall survival among all patients was 36.90 months and 3 year OS was 50.4%. Overall survival was significantly longer in those with LNR ≤ 0.65 than those with LNR > 0.65 [Mean: 39.40 months versus 29.63 months; 3 year OS 73.8% versus 23.3% respectively]. Conclusion: These results suggest that TNBC patients with lower value of LNR good prognosis than with high LNR patients. The LNR is an independent prognostic factor, thus, LNR may be added to the current staging system.
Authors and Affiliations
Mansour M Morsy, Ahmed Raafat, Abd el Motaleb Mohamed, Alaa Fayed, Mohamed Farouk Amin
Keywords
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