Progress of inhibiting epithelial-mesenchymal transition in retinal pigment epithelial cells
Journal Title: Guoji Yanke Zazhi - Year 2018, Vol 18, Issue 12
Abstract
Epithelial-mesenchymal transition(EMT)of retinal pigment epithelial cells(RPE)plays a key role in proliferative vitreoretinopathy(PVR), and also decreases the therapeutic effect of anti-vascular endothelial growth factor(anti-VEGF)to choroidal neovascularization(CNV). In addition, cells transplantation has been becoming a potential therapeutic method to treat age-related macular degeneration(AMD), and some cells sources like human embryonic stem cells(hESC)or induced pluripotent stem cell(iPSC)induced RPE cells, and fetal RPE cells have been attempted. However, EMT, as a common problem, decreases cells proliferation and differentiation efficiency, and it will reduce therapeutic effect and the number of therapeutic populations. So, in this article, we reviewed some possible methods to inhibit EMT.
Authors and Affiliations
Duo Li
Keywords
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- EP ID EP498014
- DOI 10.3980/j.issn.1672-5123.2018.12.09
- Views 158
- Downloads 0
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