PRONIOSOME AS A SUSTAINED DRUG DELIVERY SYSTEM: A REVIEW
Journal Title: International Research Journal of Pharmacy (IRJP) - Year 2012, Vol 3, Issue 10
Abstract
Proniosome were prepared by slurry method with different surfactant to cholesterol ratio. An ideal or best formulation of proniosomes based niosome is said to be one which gives high entrapment efficiency with desirable sustained release. In this study entrapment efficiency is found to be cholesterol: surfactant ratio dependent. The release rate also found to be dependent of cholesterol: surfactant ratio. For effective proniosomes, it is essential that the surfactant coating be smooth and uniform to allow for rapid and consistent hydration. SEM study reveals that the coating of the surfactant on the maltodextrin powder is uniform. Angle of repose measurements indicated that the fluidity of proniosomes dry powder is equal to or better than that of maltodextrin powder, so further processing of proniosomes powder should be straightforward.
Authors and Affiliations
Pankaj Singh , Sunil Niranjan , Raghuveer Irchhaiya
Keywords
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