Propane-1,3-sultone. Documentation of suggested occupational exposure limits (OELs)
Journal Title: Podstawy i Metody Oceny Środowiska Pracy - Year 2014, Vol 30, Issue 3
Abstract
Propane-1,3-sultone is a white crystalline solid or a colorless liquid. It is very soluble in water and readily soluble in ketones, esters and aromatic hydrocarbons. It is not known to occur naturally; it is obtained by dehydration of γ-hydroxy-propanosulfonic acid. Propane-1,3-sultone is used in the production of dyes, resins, accelerators, fungicides and insecticides. A person involved in the production of the substance or using deter-gents, corrosion inhibitors and other products manufactured from this substance can be occupationally exposed to propane-1,3-sultone.The primary routes of potential human exposure to propane-1,3-sultone are ingestion, inhalation and dermal contact. Propane-1,3-sultone very strongly irritates mucous membranes and skin, and is classified as a substance that can cause changes in the nature of sensitisation. The main symptoms of acute toxicity have been observed in animals ex-posed to apathy, bloody diarrhoea, tremors, haemorrhagic pulmonary oedema, cerebral oedema. There are no data in the literature on acute or chronic actions of propane-1,3-sultone in humans. In the available literature, there is information that this compound causes cancer in exposed workers. Results of standard experiments indicate that propane-1,3-sultone has mutagenic and genotoxic activity. Propane-1,3-sultone shows a strong car-cinogenic activity in the laboratory animals exposed by various routes. The main tumors observed in animals were related to the brain, mammary gland and cancer at the injection site after subcutaneous administration. For a concentration of 0.0074 mg/m[sup]3[/sup], the calculated risk of developing cerebral glioma is 10-3. Experts of the International Agency for Research on Cancer (IARC) have classified propane-1,3-sultone to Group 2B, i.e., factors possibly carcinogenic to humans. At its meeting on March 26, 2014, the Interdepartmental Commission for Maximum Admissible Concentrations and Intensities for Agents Harmful to Health in the Working Environment accepted a concentration of 0.007 mg/m[sup]3[/sup] for the value of MAC for propane-1,3-sultone at risk 10-3. Notations Carc. Cat. 1B and Skin is recommended.
Authors and Affiliations
JADWIGA SZYMAŃSKA, BARBARA FRYDRYCH
Keywords
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