Proper Timing of Prophylactic Antimicrobial Administration in Orthopedic Surgeries
Journal Title: Scholars Academic Journal of Pharmacy - Year 2018, Vol 7, Issue 3
Abstract
Abstract: Correct timing of administration is vital for ensuring the efficacy of prophylactic antimicrobials in preventing surgical site infection (SSI). Insufficient commitment to perioperative antimicrobial prophylaxis guidelines has been observed, but there is a rareness of information on this subject from Jordan. The main aim of this study is to find the appropriateness of administration of the first dose of prophylactic antimicrobials in orthopedic surgeries. An observational study will be performed in the Royal Rehabilitation Centre (RRC) in the Royal Medical Services (RMS); administration of antimicrobials in operations done over a 2-month period was examined. The major outcome measure will be timing of antimicrobial administration in relation to skin incision and tourniquet application. Ideal timing will be defined as prophylactic antimicrobial administration 15-60 min before skin incision or tourniquet application. There were 204 procedures out of which 190 (93.1%) were performed without a tourniquet. Of these 190 procedures, antimicrobials were given before skin incision in 106 (55.8%) procedures and administration was optimal only in 32 (16.8%) procedures. The median induction-incision interval was 19 min (range: 6-41 min). Proper timing schedule of perioperative antimicrobial administration was insufficient. Customary administration at induction of anesthesia may enhance proper timing and might be considered as in any orthopedic procedure where no local or institutional perioperative antimicrobial guidelines are available.
Authors and Affiliations
Ala’a R. Alabbadi, Tariq M. Alsabra, Shereen E. Hijazeen, Ahmad A. Hiasat, Iqbal Almomani, Tamer Alzoubi, Esra’a Alawneh, Moath F Alzoubi
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