Prospected epigenetic moderators from natural sources and drug of class NSAIDS as effective treatment options to prostate cancer
Journal Title: Journal of Acute Disease - Year 2017, Vol 6, Issue 4
Abstract
Prostate cancer (PC) is one of the most common and leading cancer amongst the males all around the world. Depending upon it long latency and cost involved in its management and treatment, there is extensive need for more personalized and economical therapeutic approach for its effective therapy. The current review here discusses agents from natural dietary sources and drug class Non-Steroidal Antinflammatory (NSAIDS) that bears chemopreventive potential to regulate PC progression & tumour development and therefore could be devised into effective future treatment strategy against PC along with its metastatic castration-resistant form. Based on the literature search the therapeutic scope of selected agents are delineated, sighting their previous activity and prospects as epigenetic moderators in specific to particular PC causing biomarkers like over expression of AKR1C3, lost intracellular glutathione/glutathione-stranferases(GSH/GST) expression, DNA hypermethylation, aberrant cell proliferation and other related factors that are thought to potentiate and aggravate the onset of PC like smoking and use of other narcotics products.
Authors and Affiliations
Vaibhav Dubey, Richard Owusu-Apenten, Shipra Tripathi, Udaya Singh, Alok Semwal
Keywords
Related Articles
- EP ID EP234495
- DOI 10.12980/jad.6.20170401
- Views 122
- Downloads 0
Acute abdomen as a clinical presentation of lymphoma: A case report
Rationale: Acute abdomen is a medical emergency that requires prompt diagnosis and management. Lymphoma is a rare cause of acute abdomen. Patient concerns: A 54 year old patient complained of repeated episodes of acute a...
Acute group accident pattern analysis (accident of university student in dormitory at night)
Living in the dormitory is usually the requirement for university students who live far from the university. The medical disorder occurring at night among the university students is rarely reported. The acute problem due...
Detection of acute and chronic toxoplasmosis amongst multi-transfused thalassemia patients in southwest of Iran
Objective: Since pre-transfusion screening for Toxoplasma gondii is not performed on blood packs, thalassemia patients are susceptible to acquiring toxoplasmosis; thus, the aim of this study was to evaluate the seropreva...
Analysis of geriatric patients with minor spinal trauma admitted to the emergency department of a university hospital
Objective: To retrospectively analyze patients aged 65 years and over, who were admitted to a level II trauma center in Turkey due to minor spinal trauma in a period of 4 years. Methods: The study included 64 patients ag...
A review of Acanthamoeba keratitis in the Middle East and Iran
Acanthamoeba keratitis, a vision-threatening disease, is caused by a free-living amoeba of genus Acanthamoeba. Amoeba is widely distributed all around the world. Several cases of Acanthamoeba keratitis have been reported...