Prospective study of apoptotic index and mitotic index as a predictor of response to radiation in subjects of squamous cell carcinoma of uterine cervix treated by radical radiotherapy
Journal Title: Indian Journal of Pathology and Oncology - Year 2018, Vol 5, Issue 2
Abstract
Introduction There exists a wide variation in the response of tumors to radiotherapy and prognosis from individual to individual after radiotherapy to carcinoma of uterine cervix in all stages Before embarking on treatment one would like to be forearmed with the knowledge that the treatment outcome would be good Apoptosis is an important mechanism in predicting response to radiotherapy in squamous cell carcinoma of uterine cervixObjective Prospective study to correlate the relation between markers of cell proliferation MI cell death AI and MI to AI ratio as an independent prognostic factors in patients of carcinoma of uterine cervix treated by radical radiotherapyMaterials and Methods 56 evaluable subjects of squamous cell carcinoma of uterine cervix during the period from May 1999 to December 1999 were enrolled in the study and patients were followed for 2 years Measurement of Apoptotic index AI and Mitotic Index MI was done by microscopic method only All subjects received radiation to a dose of 70 Gy using standard techniqueResults Patients with Apoptotic Index AI less than median value of 075 and Mitotic Index MI greater than median value of 02 showed better response to radical radiation therapy at 2 years However the difference is not statistically significant p 020 and 025 respectively Patients with AIMI less than median value of 03 showed better local as well as overall control of disease when compared to patients with AIMI ratio greater than median value of 03 The difference is statistically significant p 003Conclusions Besides traditional prognostic factors like stage lymphovasular invasion AIMI ratio will provide a guide for response to radiotherapy and prognosisKeywords Apoptosis index Mitotic index Apoptosis index to mitotic index ratio Squamous cell carcinoma of uterine cervix Response to radiation therapy and prognosis
Authors and Affiliations
Gorijavolu Durgaprasad
Keywords
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- EP ID EP475486
- DOI 10.18231/2394-6792.2018.0037
- Views 57
- Downloads 0
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