Prospective Study of Dexmedetomidine-Propofol versus Dexmedetomidine-Ketamine for Sedation and Anesthesia in Hysteroscopic Examination and Procedures
Journal Title: Indian Journal of Anesthesia and Analgesia - Year 2017, Vol 4, Issue 2
Abstract
Context: Dexmedetomidine a wonderful drug with vital organ protective properties. When combined with other intravenous anaesthetic agents useful in surgical procedure without intubation. Less research work was done on this subject.Objectives: The aim of this study was to compare the effects of dexmedetomidine +propofol with dexmedetomidine+Ketamine combinations for sedation and anesthesia in patients undergoing hysteroscopy and procedures regarding hemodynamic changes, drug requirements and the recovery criteria and postoperative complications. Patient and Methods: Sixty patients aged between 20 50 years, ASA I& II scheduled for hysteroscopy were enrolled in this study. Patients were randomly allocated into two equal groups: dexmedetomidine+propofol (DP) group and dexmedetomidine+ Ketamine (DK) group. Every patient received a loading dose of intravenous (IV) dexmedetomidine 1g/kg over 10 min and Propofol 1mg/kg (DP) or ketamine1mg/kg (DK) group and then maintained by a 0.5 g/kg/h of dexmedetomidine. Mean arterial pressures (MAP) and heart rates(HR),drug consumption,recovery time visual analog scale (VAS ) and postoperative complications were recorded. Results: The intra and post procedural HR and MAP showed statistically significant differences between the both groups throughout the procedure with lower values in DP group (p < 0.01). After procedure recovery time was significantly shorter in DK group (12.2 ± 8.2 min) compared with (15.7±9.6 min) DP group (p = 0.012). VAS was comparable in the two groups. Drug consumption similar in both the groups. Conclusion Dexmedetomidine +propofol combination as total intravenous anaesthesia showed better intra-and postprocedural hemodynamic stability with fewer complications.
Authors and Affiliations
Gopal Reddy Narra
Keywords
Related Articles
- EP ID EP466193
- DOI 10.21088/ijaa.2349.8471.42(pt-II)17.12
- Views 96
- Downloads 0
A Comparative Study of Dexmedetomidine and Clonidine as Adjuvant to Propofol for Insertion of Laryngeal Mask Airway
Objective:To evaluate theease of insertion ofLaryngeal Mask Airway (LMA) and hemodynamic response during insertion of LMA with two adjuvants, dexmedetomidine & clonidine along with induction agent propofol. Methods: Hund...
Evaluation of Vibration Sense and Motor Power Following Epidural Anaesthesia
Background: It is very important to see complete recovery from regional anaesthesia before ambulation and discharge of the patient. Bromage score or the Formal motor power test system are the conventional methods which h...
A Comparative Study of Hyperbaric 0.5% Levobupivacaine with Bupivacaine 0.5% for Spinal Anaesthesia in Elective Surgeries
Background: Subarachnoid block is popular and commonly used worldwide. The advantage of an awake patient, minimal drug cost and rapid patient turnover has made this the method of choice for many surgical procedures. Amon...
A Comparative Study of Spinal and General Anaesthesia on Maternal and Foetal Outcome in Cases of Elective Caesarean Section
International health care community is more worried about the rates of cesarean sections throughout the world. Cesarean sections are associated with temporary benefits but are associated with short and long term risks wh...
A Comparative Study of Intrathecal Dexmedetomidine with 0.5% Bupivacaine and 0.5% Bupivacaine with Placebo in Lower Abdominal Surgeries
Introduction: Spinal anaesthesia represents an attractive proposition for daycase anaesthesia, being associated with less postoperative nausea and vomiting (PONV) and better postoperative pain relief than general anaesth...