PROSTATE CANCER ASSOCIATED CHANGES IN COAGULATION AND HAEMATOLOGICAL PROFILES IN WESTERN NIGERIA
Journal Title: European Journal of Biomedical and Pharmaceutical Sciences - Year 2017, Vol 4, Issue 3
Abstract
Background: Prostate cancer is the most frequently diagnosed cancer among males. Prostate cancer has been associated with coagulation and haematological abnormalities which have contributed to the disease progression, development of disseminated intravascular coagulopathy, metastasis and other complications. This study assessed the coagulation and haematological profile of prostate cancer patients in this region. Materials and Methods: Forty prostate cancer patients and thirty apparently healthy male controls within the age range of 50-90 years old were recruited for the study. Prothrombin time (PT), partial thromboplastin time with kaolin (PTTK), packed cell volume (PCV), total white cell count (TWBC), platelet count, differential count and erythrocyte sedimentation rate (ESR) were determined using plasmascan, hemoscan reagents, Sysmex KX2-IN autoanalyser, Leishman staining technique and Westergren method respectively. Result: The study reveals a statistically significant increase in the mean ± SD of the PT, PTTK and platelet, TWBC, ESR and Neutrophils in the prostate cancer patients while the mean ± SD of the PCV, Lymphocytes and basophils decrease significantly when compared with their controls (p˂ 0.05). However, the monocytes and eosinophil in the patient group are not significantly different from those of the control group (p>0.05). Conclusion: The profiles estimated shows that the disease progression in prostate cancer is associated with presence of the cancer procoagulant as well as inflammatory markers of immunity produced in response to the condition.
Authors and Affiliations
Bamisaye E. Oluseyi
Keywords
Related Articles
- EP ID EP628135
- DOI -
- Views 203
- Downloads 0
DIPYRIDAMOLE ATTENUATES THE GASTRIC INJURY IN ADULT AND AGED FEMALE RATS
Age is one of the important factors that affect the drug effects. Gastric ulcer is a common disease especially in elderly. Patients, especially elderly, who are treated with anti-platelet drugs may be exposed to a risk o...
DEALING WITH URINARY TRACT INFECTIONS-A COMMUNITY HEALTH PERSPECTIVE:
Introduction: Urinary tract infection (UTI) is one of the most prevalent diseases affecting people of all age groups i.e. from neonate to geriatric age group. This is a problem that has got a big share in health care cos...
ASSOCIATION BETWEEN SKIN TAGS AND INSULIN RESISTANCE IN KHARTOUM STATE
Background: Skin Tags are common benign skin growth found throughout the adult populations seem to be associated with insulin resistance. Methodology: Cross sectional descriptive study involving 96 subjects with differen...
ENHANCEMENT OF IRBESARTAN DISSOLUTION VIA CONTROLLED PRECIPITATION: PREPARATION OF ORALLY DISPERSIBLE COMPACTS
Irbesartan is an antihypertensive angiotensin II receptor antagonist. It suffers poor aqueous solubility. Therefore, the aim of this work was to investigate the potential use of controlled precipitation over solid carrie...
SEASONAL DYNAMICS AND ECOLOGICAL FEATURES OF DERMACENTOR BUGS IN SOUTHERN UZBEKISTAN
Live-stock production, one of the leading sectors of the economy in the Republic of Uzbekistan, is of great importance in ensuring the high productivity of agricultural animals in the production of dairy products. From t...