Protective Effect of Alkaloids from Amaranthus Viridis Linn. Against Hydrogen Peroxide Induced Oxidative Damage in Human Erythrocytes (RBC)
Journal Title: International Journal of Clinical Endocrinology and Metabolism - Year 2015, Vol 1, Issue 1
Abstract
Plants are rich in antioxidants which play an essential role in disease prevention. Amaranthus viridis linn. Is a common medicinal plant, spread throughout the world is used in traditional ayurvedic medicine. The present study was aimed to examine the protective effect of partially purified alkaloids (PPA) from Amaranthus viridis against hydrogen peroxide induced oxidative damage in human erythrocytes in vitro conditons. The experiments are performed in groups (Control, H2O2 induced and H2O2 + 25, 50 mg conc of alkaloids). The enzymic antioxidants like CAT, SOD, GPx, GST and non enzymic antioxidants like vitamin C, vitamin E and GSH levels and LPO were evaluated to determine the protective effect of alkaloids. The alkaloids prevent the decline of antioxidant status which in turn decreases LPO levels by preventing MDA formation in erythrocytes. The results confirm the protective effect of alkaloids against free radical induced oxidative damage in human erythrocytes.
Authors and Affiliations
Sasikumar Vadivukkarasi, Subramaniam Arunambiga, Aneesh Anila, Saravanan Ganapathy
Keywords
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- EP ID EP541744
- DOI 10.17352/ijcem.000011
- Views 52
- Downloads 0
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