Two cases of traumatic isolated ACTH deficiency
Journal Title: International Journal of Clinical Endocrinology and Metabolism - Year 2018, Vol 4, Issue 1
Abstract
Case 1: A 65- year-old man was accidentally injured by wooden hammer on his top of head on 34 years before. He was suffered from vomiting, diarrhea and hypotension, and the laboratory examination revealed increased CRP level, hyponatremia and decreased plasma cortisol and ACTH levels, suggesting isolated ACTH deficiency and Crohn disease diagnosed by colonoscopic biopsy, and finally transferred to University Hospital. LH-RH, TRH, CRH and GHRP stimulation tests showed normal response of plasma pituitary hormones except for no response of plasma ACTH and cortisol levels by CRH stimulation. ACTH stimulation test showed no response of plasma cortisol levels although hydrocotisone replacement therapy had already been started. MRI imaging showed bottom of anterior lobe was crushed and pituitary gland was atrophied, which suggested brain might be injured by any strong trauma.
Authors and Affiliations
Ishizuka Tatsuo, Asano Motochika, Fujioka Kei, Mori Ichiro, Kajita Kazuo, Morita Hiroyuki
Keywords
Related Articles
- EP ID EP542567
- DOI 10.17352/ijcem.000030
- Views 54
- Downloads 0
Clinical Aspects of C-Type Natriuretic Peptide on the Cardiovascular System
C-type natriuretic peptide (CNP) is one of the three most important members of the human natriuretic peptide family, sharing with them a highly conserved 17-aminoacid ring structure, essential to elicit its biological ac...
Dipeptidyl Peptidase IV Inhibitory Activity of Berberine and Mangiferin: An In Silico Approach
Background: Dipeptidyl peptidase-IV (DDP-IV) Inhibitors may represent single anti-diabetic drugs, the multiple actions of which may translate into demonstrable therapeutic benefits in diabetes. The marketed synthetic DPP...
The Value of Positron Emission Tomography/Computerized Tomography Imaging in the Restaging of Differentiated Thyroid Cancers and Evaluation of its Association with Thyroglobulin Levels
Purpose: Recently, there have been an increasing number of studies indicating that Florine-18 fluorodeoxyglucose (FDG) positron emission tomography/computed tomography (PET/CT) is a sensitive method in the evaluation of...
Active Phytoconstituents for Controlling Hypercholesterolemia: A Review
Hypercholesterolemia is patho-physiological condition of metabolism caused by incessant increase in blood cholesterol levels and might be a possible risk factor for many cardiovascular and its associated diseases. Due to...
60-Year-Old Man with Pheochromocytoma and Clinical Picture of Depression
Introduction: Pheochromocytoma is an adrenal gland tumour, which usually produces catecholamines. The classical triad of clinical symptoms consists of palpitations, headaches and profuse sweating. Other symptoms include:...