PROTECTIVE EFFECT OF ALLOPRINOL, NIFEDIPIN, VITAMIN A AGAINST CCL4 INDUCED ACUTE LIVER INJURY IN EXPERIMENTAL RABBIT MODEL
Journal Title: World Journal of Pharmaceutical Research - Year 2017, Vol 6, Issue 12
Abstract
Objective: The present study was designed to determine the hepatoprotective effect of well Known drugs Allopurinol, Nifedipine and Vitamin-A in acute liver injury induced by Toxic agent CCL4. Materials & Methods: The normal serum values of ALP,AST,ALT and TSB & TSP were determined in 40 healthy domestic rabbits allocated to five groups-before CCL4 induction and at three occasion 24, 72,120 hr after ALI induction by CCL4 and treatment with the drugs Allopurinol, Nifedepine and Vitamin –A for five Successive days. Results: revealed significant reduction in ALP, AST, ALT&TSB levels with significant elevation in the TSP level of all the tested drugs measured at 120 hr compared with the control and their levels Measured at 72,24 hr. Conclusion: All the tested drugs possess hepatoprotective effect when they are given orally in a dose of 400mg for Allopurinol and 2mg /kg & 8500 IU/kg for nifedipine & Vitamin-A respectively. The histopathological sections of the liver tissue support the real effect of these drugs on ALI.
Authors and Affiliations
Faruk H. Al-jawad
Keywords
Related Articles
- EP ID EP674657
- DOI -
- Views 181
- Downloads 0
THE MEDICAL MYCOLOGY AND THE LEGACY OF ANTONIO GONZALEZ OCHOA
This work presents an approach of the scientific work of Dr. Antonio González-Ochoa, prominent Mexican mycologist and dermatologist. His research had a deep transcendence in the national and international medical mycolog...
ALGAE IN THE BIOTIC ASSOCIATIONS
Algae are the gems of the plant kingdoms; they have the variety of the ranges and the many kinds of the features of the taxonomical values. Algae are famous for the many kinds of the associations in the nature, although...
PREVALENCE OF NEURAL TUBE CLOSURE DEFECTS AND THE ORO-FACIAL CLEFTS, DURING THREE CONSECUTIVE YEARS (2012-2014) IN 20 PUBLIC HOSPITALS IN MOROCCO
Background: Closure of the neural tube defects and orofacial clefts are an important cause of mortality and neonatal morbidity among children. The objective of this work is to produce objective data on the current situat...
SUBCHRONIC EVALUATION OF THE ETHANOL STEM BARK EXTRACT OF ENANTIA CHLORANTHA IN RODENTS (BIOCHEMICAL, HAEMATOLOGICAL EVALUATION AND EFFECT ON BODY WEIGHT)
Enantia chlorantha is a medicinal plant used to treat malaria and other febrile illnesses in the southern and other parts of Nigeria. Aim of study: To determine the biochemical and haematological properties of ethanolic...
AYURVEDIC VIEW OF VRICHIKA DAMSHA AND ITS AYURVEDIC MANAGEMENT
Scorpion envenomation is an common global public health problem including India. Despite various species of scorpions, only few of these can be potentially lethal to humans. In India, the annual number of scorpion stings...