PROTECTIVE EFFECT OF AN HERBAL EXTRACT IN AMLODIPINE INDUCED TESTICULAR DYSFUNCTION IN RATS
Journal Title: Hygeia:journal for drugs and medicines - Year 2017, Vol 9, Issue 1
Abstract
Plan: To verify the protective effects of the ethanolic extract of Asteracantha longifolia seeds in Amlodipine induced testicular dysfunction in rats. Preface: The widely used Dihydropyridine type calcium channel blockers like Amlodipine have reported to be causing some reproductive toxicity in males. But no studies have been made so far to nullify the toxicity of this widely prescribed group of drugs. So, an attempt is done here to nullify the reproductive toxicity of Amlodipine. Methodology: Biochemical and histological parameters of testes and different sperm parameters were analysed in ten different groups of young Wister albino rats treated with Amlodipine alone, and Amlodipine along with two different doses of ethanolic extract of Asteracantha longifolia seeds for three different periods of drug administration. Outcome: Co administration of the ethanolic extract of Asteracantha longifolia seeds was found to be providing a significant protection (P<0.05) against Amlodipine induced testicular dysfunction in rats.
Authors and Affiliations
SHINI DOMINIC, Padmaja V
Keywords
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- EP ID EP332840
- DOI 10.15254/H.J.D.Med.9.2017.162
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