A COMPARATIVE EVALUATION OF IN VITRO ANTACID ACTIVITY OF TWO Tephrosia SPECIES USING MODIFIED ARTIFICIAL STOMACH MODEL.
Journal Title: Hygeia:journal for drugs and medicines - Year 2015, Vol 7, Issue 2
Abstract
Plan: The methanol extracts of Tephrosia calophylla and Tephrosia maxima (Fabaceae) roots were assessed for the antacid activity by using self-fabricated modified artificial stomach model. Preface: Tephrosia calophylla and Tephrosia maxima are two medicinal plants prevalent to Andhra Pradesh, Karnataka and Tamil Nadu. These two plants are used widely in folklore medicine for their antiulcer activity. Methodology: The preliminary chemical tests performed for the extracts showed the presence of tannins, flavonoids, glycosides, saponins and carbohydrates. Then they were evaluated for the antacid potencies by working on the parameters like determination of pH of the prepared extracts, neutralizing effects on artificial gastric acids, duration of consistent neutralization effect on artificial gastric acids and neutralization capacity. Two commercially available antacids were used as the standard. Outcome: The methanolic extract T.maxima showed potent antacid activity when compared to T.calophylla and the two standards. Hence T.maxima can be considered as a potent substitute for the synthetic antacids that are well reputed for unwanted side effects. Further investigations on in vivo preclinical and clinical studies are yet to be performed.
Authors and Affiliations
Sandhya S
DEVELOPMENT AND VALIDATION OF A RP- UFLC METHOD FOR ESTIMATION OF SYNTHETIC STEROID HORMONE DANAZOL
Plan: Danazol is a synthetic steroid hormone with anti-estrogenic and anti-gonadotropic activities drug which acts on anterior pituitary suppressant by inhibiting the pituitary output of gonadotropins indicated for the t...
HERBAL BIOACTIVES AND FOOD FORTIFICATION
he lifestyles of people worldwide have changed in the last century due to a rise in income, increased leisure time, and reduced physical activity. These new lifestyles have a considerable impact on health. Consequently,...
Synthesis and Antioxidant activity of novel Pyrazoline derivatives
Plan: A novel series of pyrazolines were synthesized through chalcones. The synthesized compounds were evaluated for various antioxidant activities. Preface: Pyrazolines belongs to five-membered nitrogen classes of co...
BIOLOGICAL PROSPECTIVE OF 4-THIAZOLIDINONE: A REVIEW
Plan: Biological prospective of 4-thiazolidinone Prologue: 4-Thiazolidinones are derivatives of thiazolidine with a carbonyl group in the 4thposition. Substitution on the 2nd,3rd and 5thpositions may be varied, but the g...
Synthesis, Anticancer Activity and Docking of somesubstituted Benzothiazoles as EGFR Tyrosine Kinase Inhibitors and Topoisomerase IIinhibitors
Plan:The present study focuses on the structure based drug design approach for anticancer activity of various substituted benzothiazoles whether as an EGFR TK inhibitor or as topoisomerase inhibitor. Preface: The develo...