A COMPARATIVE EVALUATION OF IN VITRO ANTACID ACTIVITY OF TWO Tephrosia SPECIES USING MODIFIED ARTIFICIAL STOMACH MODEL.
Journal Title: Hygeia:journal for drugs and medicines - Year 2015, Vol 7, Issue 2
Abstract
Plan: The methanol extracts of Tephrosia calophylla and Tephrosia maxima (Fabaceae) roots were assessed for the antacid activity by using self-fabricated modified artificial stomach model. Preface: Tephrosia calophylla and Tephrosia maxima are two medicinal plants prevalent to Andhra Pradesh, Karnataka and Tamil Nadu. These two plants are used widely in folklore medicine for their antiulcer activity. Methodology: The preliminary chemical tests performed for the extracts showed the presence of tannins, flavonoids, glycosides, saponins and carbohydrates. Then they were evaluated for the antacid potencies by working on the parameters like determination of pH of the prepared extracts, neutralizing effects on artificial gastric acids, duration of consistent neutralization effect on artificial gastric acids and neutralization capacity. Two commercially available antacids were used as the standard. Outcome: The methanolic extract T.maxima showed potent antacid activity when compared to T.calophylla and the two standards. Hence T.maxima can be considered as a potent substitute for the synthetic antacids that are well reputed for unwanted side effects. Further investigations on in vivo preclinical and clinical studies are yet to be performed.
Authors and Affiliations
Sandhya S
Keywords
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- EP ID EP358815
- DOI 10.15254/H.J.D.Med.7.2015
- Views 58
- Downloads 0
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