In vitro anti-inflammatory and cytotoxicity studies of two mangrove associated lichens, Dirinaria consimilis and Ramalina leiodea extracts
Journal Title: Hygeia:journal for drugs and medicines - Year 2018, Vol 10, Issue 1
Abstract
Plan: To evaluate the anti-inflammatory and cytotoxicity activity of different extracts from two different manglicolous lichens (Dirinaria consimilis and Ramalina leiodea). Preface: Inflammation is the origin of several deadly diseases like cancer, atherosclerosis, Alzheimer’s and rheumatoid arthritis. From decades, lichen extracts and its metabolites are well known in treating inflammation and cancer. Outcome: The outcome of protein denaturation method confirmed that the ethyl acetate and acetone extract of R. leiodea depicted better inhibitory profile against protein denaturation with IC50 values of 268 and 330 µg/mL Furthermore, the results of SRB assay showed that ethyl acetate and acetone extracts of both the lichens acts potently against MCF-7, DLD-1, HeLa and A549. Simultaneously, all the tested extracts depicted the low degree of specificity towards NHME, they are less toxic. Hence, further screening of these extracts may lead to the exploration of safe and potent anti-inflammatory and anticancer agents.
Authors and Affiliations
Vinay Bharadwaj Tatipamula
Keywords
Related Articles
- EP ID EP391908
- DOI 10.15254/H.J.D.Med.10.2018.174
- Views 43
- Downloads 0
In vitro anti-inflammatory and cytotoxicity studies of two mangrove associated lichens, Dirinaria consimilis and Ramalina leiodea extracts
Plan: To evaluate the anti-inflammatory and cytotoxicity activity of different extracts from two different manglicolous lichens (Dirinaria consimilis and Ramalina leiodea). Preface: Inflammation is the origin of several...
CURATIVE POTENTIAL OF HEMIN: AN INDUCER OF HEME OXYGENASE-1 ON EXPERIMENTALLY INDUCED EXCISION WOUNDS IN RATS
Plan: Hemin is a critical component of hemoglobin and induces heme oxygenase (HO), an enzyme which degrades heme in a rate limiting manner and has an important role in cellular protection against oxidative stress. This H...
DOSAGE ADJUSTMENTS OF POTENTIALLY HEPATOTOXIC MEDICATIONS IN PATIENTS WITH LIVER DYSFUNCTION
Plan: To assess the incidence of inappropriate dosing of drugs having side effects like hepatotoxicity in hospitalized patients with hepatic impairment. Preface: Inappropriate dosing in patients with liver dysfunction...
QUALITATIVE ASSESSMENT OF KAYATHIRUMENI - A SIDDHA MEDICATED OIL AS A REMEDY FOR ARTHRITIC PAIN
Plan: Kayathirumeni is an important formulation of Siddha system of medicine used to treat various human disorders. Such as myalgia, Arthritic pain etc. Preface: The present study aimed to set quality parameters in phys...
USE OF NON-PRESCRIPTION MEDICATION AMONG STUDENTS OF A UNIVERSITY IN THE U.A.E.
Plan: The study aimed to assess the use, knowledge and practice of OTC medications by students of a University in the UAE Preface: Over the Counter (OTC) drugs, also known as non-prescription medication are medications d...