Protective effect of Canthium parviflorum against potassium oxonate induced hyperuricemia in rats
Journal Title: International Journal of Research in Pharmacology & Pharmacotherapeutics (IJRPP) - Year 2018, Vol 7, Issue 3
Abstract
Canthium parviflorum, belonging to the Rubiaceae was a valuable source of new secondary metabolites, jused in ayurvedic system of medicine, for various disorders. Traditionally, various parts of Canthium parviflorum were used to treat oedema, dysentery, spasm, scabies, diabetes etc. It also used to eliminate uric acid as well as increase the urinary output. Current study was aim to evaluate the antigout property of ethanolic leaf extract of Canthium parviflorum. The study was conducted in both in-vitro and in-vivo models. Xantihine Oxidase inhibition method was used in in-vitro model and Potassium Oxonate induced hyperuricemia was adopted for in-vivo model. The Xanthine Oxidase inhibitor, Allopurinol was used as reference compound in both the models. Two dose levels (200 and 400mg/kg) of ethanolic leaf extract of Canthium parviflorum was evaluated against Potassium Oxonate induced hyperuricemia in SD rats. All the test drugs were administered once daily for 28 days and the protective effect was determined by measuring the plasma uric acid. In in-vitro model, the Canthium parviflorum showed Xanthine Oxidase inhibition activity and comparable as that of Allopurinol. In in-vivo model, both the doses of ethanolic leaf extract of Canthium parviflorum exhibited significant reduction in the plasma uric acid levels as compare to Potassium oxonate induced hyperuricemia in rats. From the results it was concluded that, ethanolic leaf extract of Canthium parviflorum produced antigout activity against Potassium oxonate induced gout in rats.
Authors and Affiliations
Asokan Balakrishnan Ramajayam
Keywords
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