PROTECTIVE EFFECT OF ORTHOSIPHON STAMINEUS LEAVES AGAINST LEAD ACETATE AND CADMIUM CHLORIDE INDUCED RENAL DYSFUNCTION IN RATS
Journal Title: International Research Journal of Pharmacy (IRJP) - Year 2013, Vol 4, Issue 4
Abstract
Though our previous study has showed that pretreatment with Orthosiphon Stamineus methanol extract (OSM) prevents gentamycin induced nephrotoxicity. No report has been documented on the effect of Pretreatment of OSM with Cadmium and Lead. Therefore this study aims to investigating the effect of pretreatment with OSM on Cadmium and Lead induced Nephrotoxicity. Nephrotoxicity was induced in Wistar rats by intraperitoneal administration of Lead Acetate 8mg/kg/day for 21 days and oral administration of Cadmium Chloride 50mg/kg for a single day. Effect of concurrent administration of Orthosiphon Stamineus leaf extract at a dose of 100mg/kg and 200 mg/kg/day given by oral route was determined using serum and urinary creatinine and blood urea and Uric acid as indicators of kidney damage. The present work demonstrates that Rat chronically intoxicated with two heavy metals display a pronounced impairment in kidney function which is confirmed by the enhancement of plasma creatinine, urea and uric acid levels, and histopathological alterations. The results of the present work showed that the cortex is more affected than the medulla due to long-term treatment with heavy metals. This could be partly due to uneven distribution of heavy metals in the tissue of the kidney where about 90% of the total renal blood flow enters the cortex via the bloodstream. Orthosiphon Stamineus Leaf extract 200mg/kg normalized the Cadmium Chloride and Lead Acetate induced increases in urine and plasma creatinine, and blood urea levels. It was observed that the Methanol extract of Orthosiphon Stamineus leaves 200mg/kg significantly protects rat kidneys from Cadmium Chloride and Lead Acetate –induced Nephrotoxicity. Orthosiphon Leaves has protective effect on lead and cadmium induced renal toxicity.
Authors and Affiliations
C. Maheswari, R. Venkatnarayanan
Keywords
Related Articles
- EP ID EP141037
- DOI 10.7897/2230-8407.4447
- Views 97
- Downloads 0
DEVELOPMENT OF FIRST ORDER DERIVATIVE ULTRAVIOLET SPECTROPHOTOMETRIC METHOD FOR SIMULTANEOUS ESTIMATION OF LEVOCETIRIZINE HYDROCHLORIDE AND PHENYLEPHRINE HYDROCHLORIDE IN BULK AND COMBINED DOSAGE FORM
The first order derivative method of ultraviolet spectrometry for simultaneous determination of Levocetirizine hydrochloride (LEV) and Phenylephrine hydrochloride (PHE) in bulk drug and combined dosage form was found to...
MOCK SURGERIES IN AYURVEDA
The present trend is very well aware of mock tests, exams and even the mock surgeries that are very common in healthcare and play an important role in providing the surgeons, the necessary practical knowledge and experti...
THE ALKALOIDS: GENUS DAPHNIPHYLLAM (DAPHNIPHYLLACEAE)
The genus Daphniphyllum comprised of about 30 species, distributed over Southeast Asia. Many plants of the genus used traditionally as folk medicine for the treatment of asthma, cough, rheumatism, inflammation, fever and...
FLAVONOIDAL CONTENT OF VANGUERIA INFAUSTA EXTRACT GROWN IN EGYPT: INVESTIGATION OF ITS ANTIOXIDANT ACTIVITY
Chromatographic purification of methanolic extract of Vangueria infausta leaves grown in Egypt led to isolation of five flavonoids namely luteolin-7-O- rutinoside, apigenin- 7-O- rutinoside, luteolin-4` -O- glucoside, qu...
EUPHORBIA NERRIFOLIA LINN: HERBAL TOOL FOR BIRTH CONTROL
In the present study, antifertility activity of hydroalcoholic extract of Euphorbia neriifolia Linn was evaluated. The ethanolic extract of Euphorbia neriifolia showed significant antifertility activity Pre treatment wit...