Protective Effect of Pycnogenol® on Cisplatin Induced-Cardiotoxicity in Rats
Journal Title: Meandros Medical and Dental Journal - Year 2018, Vol 19, Issue 3
Abstract
Objective: This study investigated the cardiotoxicity of cisplatin (CIS) on rat heart by using the oxidative damage of the rat myocardium, troponin I and serum S100A1 levels. Previous studies have reported that cell-protective effect of Pycnogenol® (PYC) depended on its antioxidant and anti-inflammatory properties. Hence, the myocardial protective effect of PYC was investigated in this study. Materials and Methods: Rats were randomly grouped to four with 5 rats in each group. The groups were consisted of control group, PYC group: 10 mg/kg PYC for 7 days, CIS group: 15 mg/kg single injection of CIS on the 5th day, CIS + PYC group: 10 mg/kg PYC for 7 days, plus 15 mg/kg single injection of CIS on the 5th day. Heart and serum samples were acquired subsequently. Results: CIS and PYC co-treatment group had increased catalase level (from 43.61±15.16 to 60.80±21.36, p<0.019) and prevented troponin I elevation (from 7.34±6.20 to 3.03±1.36). The S100A1 level was significantly reduced by CIS (from 10.25±8.8 to 3.99±2.87, p<0.035) and was restored by PYC treatment (32.07±29.23). Conclusion: Injured cardiomyocytes released troponin I after exposure to CIS and PYC, which can protect the cells from CIS cardiotoxicity, increased the tissue catalase level. Additionally, PYC treatment increased serum level of S100A1.
Authors and Affiliations
Ufuk Eryılmaz, Saliha Aksun, Buket Demirci
Keywords
Related Articles
- EP ID EP399333
- DOI 10.4274/meandros.85856
- Views 107
- Downloads 0
Bibliometric Analysis of the Most Cited First One Hundred Manuscripts in Familial Mediterranean Fever
Objective: Studies investigating cumulative scientific data about a specific subject and assessing the scientific performance are named as bibliometric analysis. Familial Mediterranean Fever (FMF) is an autosomal recessi...
A Rare Seen Hemorrhage Disorder: Factor XI Deficiency Hemophilia C
Factor XI deficiency is a hemorrhage disorder which can be either autosomal recessive or/and autosomal codominant and effects both women and men. Factor XI deficiency is uncommon in non-Jewish general population and aver...
Neuro-Behçet Disease Presenting with Sinus Venous Thrombosis: Case Report
Behçet’s disease (BD) is a rare, chronic, autoimmune, autoinflammatory disorder of unknown origin. Mucocutaneous lesions and panuveitis constitute the hallmark of Behçet's. The disease is mostly seen at the third decade...
Shprintzen-Goldberg Syndrome: Case Report
Shprintzen-Goldberg syndrome is a rare syndrome with craniosynostosis of coronal, sagittal or lambdoidal sutures, dolichocephaly, typical craniofacial features, skeletal abnormalities, scoliosis, joint hyperextensibility...
Effect of Initial Periodontal Treatment on Cardiovascular Risk Markers in Patients with Severe Chronic Periodontitis
Objective: The aim of the study was to determine the influence of initial periodontal treatment in patients with severe chronic periodontitis on inflammatory markers related to risk for cardiovascular diseases. Materials...