PROTECTIVE EFFECT OF ROOT EXTRACT OF WITHANIA SOMNIFERA ON 1,4-DIOXANE AND TRICHLOROETHYLENE-INDUCED CHANGES IN LIPID PEROXIDATION IN ERYTHROCYTES OF INVITRO GOAT HAEMIC SYSTEM
Journal Title: Journal of Drug Discovery and Therapeutics - Year 2013, Vol 1, Issue 6
Abstract
Our environment is being contaminated daily with verities of chemicals from several industries during their manufacture, distribution, use and disposal. Thus chronic exposure of animals and humans to toxic environmental pollutants is a global health concern. Upon exposure to these chemicals like 1,4-Dioxane and Trichloroethylene, the vital organs and functions of the body are being affected. The Ashwagandha (Withania somnifera L.) is an Ayurvedic medicinal plant which is popular as a home remedy for several diseases would have some protective effect against these chemicals.The present study reveals the effects of 1,4-Dioxane and Trichloroethylene in lipid peroxidation in erythrocytes of goat haemic system in-vitro and assess the protective effect of Withania somnifera root extract against the changes in lipid peroxidation induced by these two environmental pollutants.
Authors and Affiliations
Neetu Bharti| Bhagwant Institute of Pharmacy, Muzaffarnagar, Uttar Pradesh, India-251315, Shilpi Arora| Bhagwant Institute of Pharmacy, Muzaffarnagar, Uttar Pradesh, India-251315, Devendra Pratap Singh*| Bhagwant Institute of Pharmacy, Muzaffarnagar, Uttar Pradesh, India-251315, Ankit Saini| Bhagwant Institute of Pharmacy, Muzaffarnagar, Uttar Pradesh, India-251315, Ashish Kumar| Bhagwant Institute of Pharmacy, Muzaffarnagar, Uttar Pradesh, India-251315
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