Protective Effect of Vitamin B5 (Dexpanthenol) on Nephropathy in Streptozotocin Diabetic Rats
Journal Title: Meandros Medical and Dental Journal - Year 2021, Vol 22, Issue 1
Abstract
Objective: This study aimed to evaluate the effects of vitamin B5 [dexpanthenol, DEX] treatment on the kidney in a streptozotocin (STZ) diabetes animal model. Materials and Methods: Twenty-four Wistar rats were randomised in one of the four groups: Group 1 served as control, and group 2 was administered high-dose DEX (300 mg/kg/day) as a safety group. Diabetes was induced by intraperitoneal injection of a single dose of STZ (50 mg/kg) in groups 3 and 4. In group 4, DEX was administered as well. All groups were followed up for 6 weeks. Histopathological analyses were performed on renal tissue using periodic acid-Schiff and Hematoxylin- Eosin stains. Results: Microscopic evaluation of the kidney revealed that the rats demonstrated kidney damage 6 weeks after STZ administration. However, high-dose and longterm DEX administration alone did not damage renal tissue; moreover, kidney damage was prevented if DEX was administered in the early phase of diabetes. Conclusion: DEX could be a safe and cost-effective vitamin for the prevention of diabetes complications.
Authors and Affiliations
Nazli Gulriz Ceri, Kanat Gulle, Mehmet Arasli, Meryem Akpolat, Buket Demirci
Keywords
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- EP ID EP693427
- DOI 10.4274/meandros.galenos.2021.65002
- Views 112
- Downloads 0
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