PROTECTIVE EFFECTS OF CACTUS AND/OR PAPAYA JUICES AGAINST HEPATIC AND TESTICULAR TOXICITY INDUCED BY CHLORPYRIFOS IN ALBINO RATS
Journal Title: World Journal of Pharmaceutical Research - Year 2019, Vol 8, Issue 10
Abstract
This study aimed to evaluate the effect of cactus and/or papaya juices on chlorpyrifos induced toxicity in ratʼs liver and testes. A total of sixty albino rats weighing (180g -200g) were used for this study. Rats were divided into 5 groups each of 12 rats. First group was left as control group. Second group was given chlorpyrifos 6mg/kg b wt. The other three groups were given cactus, papaya juices and both of them as 20ml/kg b wt, subsequently along with chlorpyrifos dose. All doses were orally administered daily for 28 successive days. At the end of the experimental period, blood samples, liver and testes were collected from each rat for biochemical analysis. Oral administration of chlorpyrifos for 28 days in a dose of 6 mg/kg bwt, significantly increased the percentage of DNA fragmentation, caspase-3 level in liver and testes tissues. A significant increase in serum alanine aminotransferase, aspartate aminotransferase, catalase, cytochrome P450, paraxonase-1 activity as well as tumor necrosis factor- α, malondialdehyde and follicle stimulating hormones levels and decrease in testosterone and luteinizing hormone levels was observed. On the other hand the administration of tested chlorpyrifos with juices, reduce the percentage of DNA fragmentation, caspase-3 level and directed enzymes activity and hormones levels toward normal. The effect on the liver is one of the main toxic effects of this product. In conclusion cactus and papaya juices have beneficial effects as it tends to dampen chlorpyrifos toxicity in rats.
Authors and Affiliations
Dr. Huda E. Mogahed
Keywords
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