PROTECTIVE EFFECTS OF ETHANOLIC LEAF EXTRACTS OF CORCHORUS FASCICULARIS IN PHENYLHYDRAZINE INDUCED ANEMIC RATS
Journal Title: International Journal of Pharmacognosy - Year 2017, Vol 4, Issue 12
Abstract
The aim of the present study is to evaluate the anti anemic activity of ethanolic leaf extract of Corchorus fascicularis against phenylhydrazine induced hemolytic anemia in rats. Phenylhydrazine (40mg/kg) was administered intraperitoneally for 2 days to induce anemia in rats. The animals were divided in to five groups of 6 animals each. Group I served as normal control, group II as anemic control, group III as reference control administered with Vitamin B12 and group IV and V animals were treated with 100 mg/kg and 200mg/kg of ethanolic leaf extract of Corchorus fascicularis Linn. (CFE). All the test drugs were administered once daily for 28 days through oral route. On 1st, 14th and 28th day blood was withdrawn, through sinus puncture under phenobarbitone anesthesia and subjected to the estimation of RBC, Hb and percentage Hematocrit. Both the ethanolic leaf extracts of Corchorus fascicularis Linn. and Vitamin B12 significantly increased the RBC, Hb and Hematocrit levels which conclude that, Corchorus fascicularis Linn. leaf extract exhibits anti-anemic activity.
Authors and Affiliations
Vikas S. Shende et al.
Keywords
Related Articles
- EP ID EP428734
- DOI -
- Views 47
- Downloads 0
COMPARATIVE STUDY OF IN VITRO ANTHELMINTIC ACTIVITY OF SAP OF AZADIRACHTA INDICA (NEEM)
The present study was designed to judge the in vitro anthelmintic activity of Sap of Azadirachta indica. The duct roundworm, Pheretima posthuma, has been reported to cause severe health issues in immeasurable folks round...
ANTIHYPERLIPIDEMIC ACTIVITY OF ETHANOLIC EXTRACT OF AMORPHOPHALLUS PAEONIIFOLIUS TUBER IN TRITON WR 1339 INDUCED HYPERLIPIDEMIC RATS
Hyperlipidemia is the most prominent risk factor of coronary heart disease. The present study was designed to investigate the anti-hyperlipidemic activity of Amorphophallus paeoniifolius Tuber in Triton WR-1339 induced h...
ACUTE AND SUB-ACUTE TOXICITY STUDY ON SIDDHA DRUG MAGIZHAM PATTAI CHOORANAM IN RODENTS
Infertility is one of the most extremely tragic all over the world. Despite recent advances in the treatment of male infertility, the problem has not been satisfactorily tackled. The male infertility is mainly due to an...
EVALUATION OF ANALGESIC ACTIVITY OF THE DIFFERENT FRACTIONS OF TYPHA ELEPHANTINA ROXB.
This study was aimed to investigate the analgesic activity of the different fractions of Typha elephantina Roxb. Analgesic activity was evaluated for peripheral pharmacological actions using the acetic acid-induced writh...
ANTI- NOCICEPTIVE ACTIVITY OF SPIRULINA PLATENSIS IN MICE
Spirulina platensis is a blue-green alga that widely used as a food supplement over worldwide. Two models were used to study the effects of Spirulina platensis on nociception which was induced by acetic acid (Writhing te...