Protective Effects of Imatinib and Ginkgo Biloba on Cisplatin-induced Ovarian Damage in Rats
Journal Title: Istanbul Medical Journal - Year 2020, Vol 21, Issue 4
Abstract
Introduction: In our study we aimed to observe the protective effects of imatinib and ginkgo biloba (GB) on cisplatin (CP)- induced ovarian damage in rats. Methods: Thirty-two female rats were included and assigned to four groups. Group 1 had no medication. Their ovaries were removed for examination and the serum Anti-Mullerian hormone (AMH) levels were measured. Group 2 received a single dose of 7.5 mg/kg intramuscular CP. Group 3 received a single dose of 7.5 mg/kg oral imatinib and 30 minutes later, a single dose of 7.5 mg/kg intramuscular CP was administered. Group 4 received 80 mg/kg oral GB for 10 days. Sixty minutes after the first administration of the GB, a single dose of 7.5 mg/kg intramuscular CP was administered. The ovaries and serum AMH levels of the rats were assessed after 10 days of observation. Results: Comparing group 1 and 2 showed that the total histopathological ovarian damage scores increased in the latter (p=0.044). This group also had decreased primordial follicles, preantral follicles and serum AMH (p=0.001, p=0.004 and p<0.001 respectively). In group 3, total histopathological ovarian damage score increased (p=0.020), and a reduction in primordial follicles (p=0.008) and serum AMH levels (p<0.001) was observed. In group 4, total histopathological ovarian damage score increased (p=0.016) as in groups 2 and 3. There was also a reduction in primordial follicles, preantral follicles and serum AMH levels (p<0.00, p=0.010 and p<0.001 respectively). Conclusion: It was concluded that imatinib and GB were not effective in preventing CP-induced ovarian damage in rats.
Authors and Affiliations
Önder Sakin, Ali Doğukan Anğın, Kazibe Koyuncu, Muzaffer Seyhan Çıkman, Kayhan Başak, Asuman Orçun Kaptanağası
Keywords
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- DOI 10.4274/imj.galenos.2020.46667
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