Protective effects of Macrotyloma uniflorum seeds (horse gram) in abnormalities associated with the metabolic syndrome in rats
Journal Title: Journal of Diabetes and Obesity - Year 2015, Vol 2, Issue 1
Abstract
Macrotyloma uniflorum Lam Verdc known as horse gram is an underutilized - unexplored legume distributed throughout Asia - Africa Its seeds are rich in antioxidant phenolic acids ferulic acid being the most potent one The present study evaluates the protective effects of a hydroalcoholic extract of the seeds of Macrotyloma uniflorum MUSE - ferulic acid in hyperlipidemia - cardiac abnormalities associated with the metabolic syndrome in rats Isolation - quantification of ferulic acid from MUSE was carried out by HPTLC - HPLC respectively Abnormalities associated with the metabolic syndrome were induced in rats by administering them fructose 25 w v in drinking water for 45 days MUSE 200mg kg - 400mg kg ferulic acid 80mg kg - the st-ard drug gemfibrozil 60mg kg were administered to rats along with fructose MUSE - ferulic acid treatments elicited significant cardioprotective activity by attenuating the fructose-elevated activities of the marker enzymes AST LDH - CK-MB in serum - by restoring the fructose depleted activities of these enzymes in heart Both treatments attenuated significantly the fructose elevated malondialdehyde levels - restored the fructose depleted glutathione levels - activities of the antioxidant enzymes superoxide dismutase catalase glutathione peroxidase - glutathione reductase in heart A significant alteration in lipid profile notable decrease in cardiac hypertrophy left ventricular hypertrophy heart collagen - blood glucose levels - improved glucose tolerance was observed in the treatment groups when compared with the fructose fed animals The present findings suggest that MUSE may be useful as an adjuvant for the management of hyperlipidemia - cardiac abnormalities associated with the metabolic syndrome The potent antioxidant activity of its phenolic phytoconstituents particularly ferulic acid may be a major factor towards this activity
Authors and Affiliations
V-ana S. P-a
Keywords
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- EP ID EP417818
- DOI 10.15436/2376-0494.15.020
- Views 116
- Downloads 0
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