PROTECTIVE EFFECTS OF ZINGIBER OFFICINALE AGAINST CARBON TETRACHLORIDE INDUCED LIVER FIBROSIS
Journal Title: International Journal of Pharmacy and Pharmaceutical Sciences - Year 2016, Vol 8, Issue 3
Abstract
Objective: Liver plays a pivotal role in regulating various physiological processes in the body such as metabolism, secretion, and storage. It has a great capacity to detoxify toxic substances and synthesize useful principles. The current study was designed to investigate the possible protective effects of Zingiber officinale (ginger) extract on liver fibrosis induced by carbon tetrachloride (CCl4) in rats.Methods: The animals were divided into four groups with eight rats in each. To induce liver fibrosis, Wistar albino rats received CCl4 (2 ml/kg diluted in corn oil) twice weekly for eight weeks. Rats were concurrently treated with Z. officinale extract at two different doses (300 and 600 mg/kg/day).Results: CCl4 ÂÂinduced liver injury characterized by fibrotic changes, degenerated hepatocytes and focal accumulation of inflammatory cells. In addition, CCl4 administration produced a significant increase in serum aminotransferases, lipids, liver lipid peroxidation and nitric oxide. The hepatoprotective effects of Z. officinale extract were evidenced by the significant decrease in serum aminotransferases and liver lipid peroxidation. Further, concurrent treatment with either dose of Z. officinale enhanced liver glutathione and enzymatic antioxidant defenses.Conclusion: Z. officinale showed a marked hepatoprotective effect against CCl4–induced liver fibrosis and injury through the abolishment of oxidative stress and potentiation of the antioxidant defense system.Keywords: Antioxidant, Ginger, Fibrosis, Oxidative stress
Authors and Affiliations
Iman H. Hasan, Mohamed A. El-desouky, Ghada M. Abd-elaziz, Walaa G. Hozayen
Keywords
Related Articles
- EP ID EP577822
- DOI -
- Views 34
- Downloads 0
EMERGING TRENDS IN PATIENT COUNSELLING: CURRENT SCENARIO
Objective: To evaluate the impact of patient counselling in terms of knowledge, attitudes and practices (KAP) outcomes among retail and hospital pharmacist in Satara and Sanagli district.Methods: A cross-sectional survey...
A STUDY ON KNOWLEDGE, ATTITUDES, AND PRACTICES FOR THE PREVENTION OF DIABETIC FOOT IN RURAL TERTIARY CARE TEACHING HOSPITAL
Objective: To assess the knowledge, attitude, and practice of diabetic patients regarding care of their own feet.Methods: This is a cross-sectional study conducted in the inpatient department of surgery at Adichunchanagi...
MIPOMERSEN: A NOVEL THERAPEUTIC DRUG FOR THE TREATMENT OF FAMILIAL HYPERCHOLESTEROLEMIA, HYPERLIPIDAEMIA, AND HYPERCHOLESTEROLEMIA
Familial Hypercholesterolemia (FH) is one of the most common autosomal dominant disorders which exist in either heterozygous form or a homozygous form. These two forms are prevalent in1 in500 and1 ina million population...
ANTIOXIDANT AND ANTIINFLAMMATORY EFFECTS OF VITEX NEGUNDO ON FREUND’S COMPLETE ADJUVANT INDUCED ARTHRITIS
Objective: Vitex negundo, commonly known as “nirgundi†is widely used in traditional as well as in folk medicines to cure many ailments such as fever, rheumatism, gum and skin diseases and liver disorders, etc. The p...
ANTIBIOTIC PRESCRIPTION TO PEDIATRIC IN HOSPITAL BENGKULU, INDONESIA: ATC/DDD INDEX
Objective: The aim of this study was to evaluate the utilization of antibiotics for children in the General Hospital of Dr. M. Yunus Bengkulu, Indonesia by using the ATC/DDD index, which is accepted as a standard method....