PROTECTIVE EFFICACY OF HUMBOLDTIA BRUNONIS WALL ON DOXORUBICIN INDUCED OXIDATIVE DAMAGE
Journal Title: International Research Journal of Pharmacy (IRJP) - Year 2012, Vol 3, Issue 2
Abstract
Liver, heart and kidney are the frequent targets of the toxicants as liver involved in metabolism, heart supplies O2 to entire body and kidney involves in the excretion and re-absorption of the substances. The principle cases of doxorubicin toxicity are decreased activities of antioxidant enzymes and generation of free radicals. The main objective of this work is to develop an organo-protective agent from Humboldtia brunonis. Wall which can be used against doxorubicin induced oxidative damage. After the preliminary phytochemical screening and acute toxicity study, the methanolic extract of H.brunonis.Wall was evaluated for the presence of in-vitro antioxidant activity using DPPH, superoxide radical, hydroxyl radical, nitric oxide radical scavenging and lipid peroxidation assays using doses of 200 mg/kg and 400 mg/kg. The cardioprotective effects of H. brunonis using the levels of cardiac marker enzymes(CPK and LDH), the hepatoprotective effects using the levels of liver marker enzymes(GOT, GPT and ALP) and the nephroprotective effects using the levels of kidney markers(creatinine and urea) in serum were evaluated in the present study. The results indicate that H. Brunonis Wall extract is capable of direct free radical scavenging effects and enhancing the hepato, cardio and nephro-protective activities against the doxorubicin induced oxidative damage to the vital organs.
Authors and Affiliations
Palanisamy P, Srinath K. R. , Yoganand Kumar, Pooja Chowdary
Keywords
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