Protective role of Salvia officinalis against formalin induce nephrotoxicity in Swiss albino mice
Journal Title: IOSR Journal of Pharmacy and Biological Sciences (IOSR-JPBS) - Year 2019, Vol 14, Issue 1
Abstract
Formalin is a constituent from many item of daily use including foods, Thus this study aimed to evaluate the histological changes induced by formalin on the kidney of adult male mice and evaluating the possible ameliorative role of salvia officinalis. Healthy male albino mice 8-10 weeks old weighting 24 - 30 gm were divided equally into four groups (n = 15 per group). The first group was given only the standard diet and served as the control, the second group was treated orally with aqueous extract of S. officinalis leaves (120 mg/kg bw.) for 3 successive weeks , the third group was administered with formalin (2.4 ml/kg body weight ) in drinking water for 3 successive weeks and the fourth group was Co-treated with formalin and S. officinalis. The specimens of kidney were processed for histological study by light microscopy. Histological examinations revealed that administration of formalin only exhibited marked glomerular and tubular lesion included vacuolization and swelling the lining epithelium of tubules, inflammatory cells infiltration and hemorrhage in the interstitial tissue, necrotic or desquamation lining epithelium in the luminal tubules, intratubular esinophilic casts in some renal tubules, completely obscured or stenosis urinary space of renal corpuscles, shrinkage glomeruli of some renal corpuscles with widening urinary space, many glomeruli appeared with less cellularily, dilation and congestion blood vessels. In contrast administration of S. officinalis along with formalin induced ameliorating change in renal tissue of formalin intoxicated mice.
Authors and Affiliations
Ajlal A. Alzergy, Saad M. S. Elgharbawy, Ensaf. H. Abdalwahed
Keywords
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- EP ID EP441078
- DOI 10.9790/3008-1401016669.
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