Protein binding predictions in infants

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Protein binding predictions in infants

Journal Title: The AAPS Journal - Year 2002, Vol 4, Issue 1

Abstract

Plasma binding protein levels are lower in the newborn than in the adult and gradually increase with age. At birth, human serum albumin (HSA) concentrations are close to adult levels (75%–80%), while alpha 1-acid glycoprotein (AAG) is initially half the adult concentration. As a result, the extent of drug binding to HSA is closer to that of the adult than are those drugs bound largely to AAG. A model that incorporates the fraction unbound in adults and the ratio of the binding protein concentration between infants and adults successfully predicted the fraction unbound in infants and children.

Authors and Affiliations

Patrick J. McNamara, Jane Alcorn

Keywords

plasma protein binding fraction unbound infants children newborn albumin alpha 1-acid glycoprotein

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EP ID EP681994
DOI 10.1208/ps040104
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