Psoralen - Sunlight (PUVASOL) Vs Narrow-Band Uvb Photo Therapy In Treatment Of Vitiligo: Evidence Based Prospects For Future
Journal Title: National Journal of Medical and Dental Research - Year 2018, Vol 6, Issue 3
Abstract
Background:The combination of treatment with psoralen followed by sun exposure (PUVASOL) is a well-established treatment for vitiligo, but it has many disadvantages. In the past decade, there have been reports of good efficacy using narrow band UV- B therapy. Narrow-band ultraviolet B (NBUVB) is an emerging, effective and safe treatment alternative for vitiligo. Aims: To compare the efficacy of oral PUVASOL therapy with narrow band Ultraviolet-B (NB-UVB) therapy in the treatment of vitiligo. Settings and Design:Prospective comparative analysis was performed on 64 Patients presenting to the Skin and VD Department of Nalanda Medical College & Hospital, Patna and diagnosed as a case of vitiligo. Methods and Materials:Patients were divided in two groups. 32 patients in each group were treated with PUVASOL and NB UVB therapy thrice weekly. 54 patients (26 in group A and 28 in group B) completed the treatment for 6 months. Results about the repigmentation, color match, adverse effects and stability were compared in both treatment groups. Statistical analysis used:Analysis was performed using Statistical Package for Social Sciences software (version 16; SPSS). Comparisons of the 2 treatment groups were made using the exact χ2 test and statistical significance was assumed at P<0.05. Results:19 (67.85%) of 28 patients in the NB-UVB treated group showed more than 50% repigmentation compared with 10 (38.46%) of 26 in PUVASOL treated group (p< 0.05). Colour match of the treated area to the surrounding normal skin was found better in NBUVB-treated patients 25(89.28%) as compared to the PUVASOL group 10(38.46%). After 6 months of stopping treatment stability of repigmentation with surrounding skin was almost equal in both the groups. Conclusion:We showed that NBUVB showed better therapeutic effects in inducing repigmentation and color match than PUVASOL therapy and lacks psoralen and sunlight related side effects. Therefore, it could be used as one of the first line medications in the treatment of vitiligo.
Authors and Affiliations
Katroliya Preetam S, Ravindra Singh, Ramawtar Singh
Keywords
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