Psoriasis: the choice of optimal topical corticosteroid drug
Journal Title: Український журнал дерматології, венерології, косметології - Year 2019, Vol 0, Issue 1
Abstract
Psoriasis is an immune-mediated skin disease that occupies one of the leading positions in the morbidity structure of the population of Ukraine. The main mechanism of triggering immunopathological processes in the skin is altered activity of CD4+, CD8+ T-lymphocytes, the synthesis of a number of pro-inflammatory cytokines (tumor necrosis factor a, interleukins-6, -8, -17, etc.) and growth factors (transforming growth factor a, vascular endothelial growth factor and others). The problem of treating psoriasis does not lose its relevance, despite the emergence of new methods of therapy and requires a personalized approach. The Ukrainian protocol for the management of patients with psoriasis (2015) determines topical glucocorticosteroids as first-choice therapy for mild or moderate psoriatic skin lesions and only in the absence of a clinical effect from monotherapy with external agents or their combinations the possibility of other types of treatment is considered. Сorticosteroids, which have a powerful effect on various parts of the pathogenesis of dermatosis, represent a unique opportunity to directly affect the lesions and, accordingly, suppress the inflammatory process in the skin, significantly reduce or eliminate subjective symptoms without resorting to systemic treatment. The effectiveness of modern topical steroids in the treatment of plaque psoriasis has level I evidence (recommendations of level A). The drug of choice in treating patients with psoriasis is the original synthetic steroid mometasone furoate 0.1 % (ointment, cream and lotion Elocom). The drug is characterized by the ability to quickly and durably block the synthesis of proinflammatory cytokines and reduce the severity of inflammation. Its predominantly extragenomic mechanism of action, high lipophilicity and minimal systemic absorption reduce the risk of side effects. Topical steroid mometasone furoate 0.1 % provides quick clinical effect, ease of use due to universal dosage forms, and safety when used correctly.
Authors and Affiliations
L. A. Bolotna
Keywords
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- EP ID EP577241
- DOI 10.30978/UJDVK2019-1-55
- Views 106
- Downloads 0
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