Psychobiotics as integrative therapy for neuropsychiatric disorders with special emphasis on the microbiota-gut-brain axis.
Journal Title: Biomedicine & Prevention - Year 2017, Vol 2017, Issue 2
Abstract
The human gut is home to 1014-1015 microorganisms, consisting of mainly anaerobic bacteria, but also viruses, protozoa, fungi and archaea. The gut microbiome has a dynamic nature and can be influenced by a variety of factors. The colonization of the infant gut begins at birth with the exposure of the newborn to maternal and hospital environment. Interestingly, gut microbiota is critical to brain development and function. The bidirectional communication between the gut and the brain is known as the gut-brain axis. This term has been expanded to microbiota-gut-brain axis, since gut microbiota is of primary importance to this pathway. Gut microbiota plays also an important role in behavior and mood. In fact, gut microbiota has been tightly associated with disease, ranging from gastrointestinal, through metabolic, to mental disorders, including stress, anxiety and depression. Consumption of probiotics can modulate the microbial composition, thus conferring beneficial effects and preserving host physiology. The focus of this review is the role of gut microbiota in specific neurological disorders and the preventive and therapeutic potential deriving from modulation of gut composition with probiotics in such psychiatric conditions.
Authors and Affiliations
Gemma Lou De Santis, Magdalini Kavvadia, Nuha Abd Almajeed Abbaas Alwardat, Giulia Bigioni, Carmen Zeppieri, Stefano Cascapera, Allegra De Lorenzo
Keywords
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- EP ID EP335032
- DOI 10.19252/00000006F
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