PSYCHOPHARMACOLOGICAL SCREENING OF CYLISTA SCARIOSA ROXB. LEAVES IN MICE
Journal Title: Innoriginal: International Journal Of Sciences - Year 2015, Vol 2, Issue 4
Abstract
The aqueous and ethanolic exrracts of Cylista scariosa Roxb. leaves were evaluated for its psychopharmacological activities in several experimental models using swiss albino mice. Use of the elevated plus-maze test revealed that aqueous (100 mg/kg and 200 mg/kg, i.p) and ethanolic (50, 100 and 200 mg/kg, i.p) extracts of Cylista scariosa and standard drug diazepam (1 mg/kg, i.p) increased the percentage of time and entries spent in open arms. Chronic treatment with the aqueous (100 mg/kg and 200 mg/kg, i.p) and ethanolic (50, 100 and 200 mg/kg, i.p) extracts of Cylista scariosa leaves, were able to decrease the immobility time of mice to forced swim tests and the effects were comparable to that of standard drug imipramine (15 mg/kg, i.p). The mice treated intraperitoneally with reserpine (5 mg/kg) were submitted to increased catalepsy and tremors time. Treatment with aqueous (100 mg/kg and 200 mg/kg, i.p) and ethanolic (50, 100 and 200 mg/kg, i.p) extracts of Cylista scariosa leaves antagonized the reserpine induced catalepsy and tremors time these effects comparable to standard drug Levodopa (150 mg/kg, i.p). All these results were compared with respective controls for the evaluation of significance. The presence of flavonoids, glycosids, tannins and L-dopa in the aqueous and ethanolic extract of Cylista scariosa leaves might be responsible for anxiolytic, antidepressant and antiparkinsonian activity of Cylista scariosa extracts. Cylista scariosa extracts may have potential therapeutic value for the management of psychopharmacological disorders.
Authors and Affiliations
Lokesh T. Thakre, Angad Patole, Meher Tundulvar, Sumit Rathod
Keywords
Related Articles
- EP ID EP444961
- DOI -
- Views 142
- Downloads 0
APPLICATION OF TLC DENSITOMETRIC METHOD FOR SIMULTANEOUS DETERMINATION OF ASPIRIN AND OMEPRAZOLE IN PHARMACEUTICAL PREPARATION
Objective: Thin layer denistometric method has been developed for simultaneous determination of aspirin and omeprazole in their new pharmaceutical dosage form. Methods: The densitometric separation process was performed...
REDUCING POSTHARVEST LOSSES IN NIGERIA’S AGRICULTURAL SECTOR: PATHWAY TO SUSTAINABLE AGRICULTURE.
The study focused primarily on postharvest losses which are like a recurring decimal in Nigeria’s agricultural sector, the driving factors and proactive measures that can be adopted to tackle the problem. Nigeria’s popul...
PHARMACOLOGICAL SCREENING FOR ANTI-OBESE ACTIVITY OF AQUEOUS ROOT EXTRACT FROM IPOMOEA SEPIARIA KOENING EX. ROXB IN HIGH FAT DIET-INDUCED OBESE MALE WISTAR RATS.
Effect of Ipomoea sepiaria aqueous root extract on high cholesterol diet rats was investigated. Obesity was induced in rats by giving high cholesterol diet (coconut oil, grains, sugar, etc) for seven days in standard rat...
A COMPARATIVE CLINICAL EVALUATION OF ACACIA CATECHU (LINN. F.) WILLD. & AZADIRACHTA INDICA (A. JUSS.) W.S.R. TO DIABETES MELLITUS
Objectiv: Comparison of effectiveness of drug Khadira twak churna in Group A and Nimba twak churna in Group B given same dose on patients of Diabetes mellitus. Method: Patients between 30-70 yrs. of age with clinical si...
PHYTOMEDICINAL IMPORTANCE OF MIMUSOPS ELENGI: AN EMERGING PRESENT AND PROMISING FUTURE
The practices of traditional medicine are based on hundreds of years of belief and observations and analysis, which help in the development of modern medicine. Today, there is widespread interest in herbal drugs. Maulsar...