Pulmonary Function Parameters in Healthy Nepalese Population
Journal Title: INTERNATIONAL JOURNAL OF CURRENT RESEARCH IN MEDICAL SCIENCES - Year 2016, Vol 2, Issue 8
Abstract
Background: The variables of pulmonary function tests are interpreted in relation to normal reference values but they can be affected by various factors like socio-economic, geographical, climatic, nutritional conditions and many more.Objective: To establish and introduce our own Nepalese population specific reference range of Lung Function Test parameters for the clinical interpretation rather than using the reference range and prediction equations provided in commercial equipment done in different races which does not match up with Nepalese population. Materials and Methods: The study population consisted of 300 healthy volunteers aged 18 to 60 years belonging to different ethnic groups of Nepal. The subjects were instructed to perform three acceptable and reproducible maneuvers so as to get highest possible peak flows. The pulmonary function parameters like VC, FVC, FEV1, PEF, PEF25andPEF75 which are frequently used by clinicians to differentiate restrictive and obstructive airways diseases and overall respiratory health were taken for analysis. Result: In present study, comparison of pulmonary function parameters between actual measured values of Nepalese population with that of predicted value provided in commercial equipment shows significant difference i.e. the pulmonary function parameters like VC, FVC, FEV1, PEF, PEF25 shows significant decrease in actual measured value (p<0.05) while significant increase in FEV1 % in Nepalese population as compared to that of predicted values. Also, the study revealed that all the pulmonary function parameters like TV, VC, FVC, FEV1, PEF, PEF25 and PEF75 is significantly greater in non-mongoloid than compared to mongoloid ethnic group of Nepal. Likewise, the correlation analysis of age was significantly negatively (P<0.001) correlated with VC, FVC, FEV1, PEF, PEF25 and PEF75 while significantly positively correlated (P<0.001) with height. Likewise, weight and body surface area were significantly positively correlated with TV, VC, FVC, FEV1, PEF and PEF25.Conclusion: In conclusion, from our study, we can say that there cannot be any single universal equation that can be predictor for all groups of people. The use of reference range of pulmonary function parameters from a country as near as India and china is also not relevant and can give a misleading picture.
Authors and Affiliations
Santosh Kumar Deo1 , Santosh Dev2
Keywords
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