In-vitro Anti-Urolithiatic Activity of Aerial parts of Aerva lanata (L.) Juss
Journal Title: INTERNATIONAL JOURNAL OF CURRENT RESEARCH IN MEDICAL SCIENCES - Year 2016, Vol 2, Issue 3
Abstract
Urolithiasis is a complex process that occurs from series of several physicochemical event including super-saturation, nucleation, growth, aggregation and retention within the kidneys. Data from in-vitro, in- vivo and clinical trials reveal that phytotherapeutic agents could be useful as either alternative or an adjunct therapy in the management of Urolithiasis. Medicinal plants / natural products are more useful for body because they promote the repair mechanism in natural way. Various plant species of Aerva lanata (L.) have been reported to posses antiurolithiatic property. In this study aqueous, chloroform, benzene extracts of Aerva lanata (L.) and standard for dissolving kidney stones- calcium oxalate by an in-vitro model. To check their potential to dissolve experimentally prepared kidney stones- calcium oxalate by an in-vitro model for Aerva lanata (L.) and cystone as a standard compound collected from market. Phenolic compound isolated from the benzene and aqueous, flavanoids and steroids from aqueous fraction of the leaf. Aqueous fractions showed highest dissolution of stones as compare to others. Aqueous fraction was more effective in dissolving calcium oxalate (54.5±0.022%). Phenolic and flavanoids fractions of Aerva lanata (L.) were found to be more effective when compared to reference standard-formulation Cystone.
Authors and Affiliations
Dr. K. Saravanasingh, M. D. (S)1* Dr. M. Ramamurthy, M. D. (S)2 and Dr. P. Parthiban, M. D. (Siddha)3
Keywords
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