QSAR AND DOCKING STUDIES OF INDENE N-OXIDE DERIVATIVES AS PPARΓ AGONISTS
Journal Title: Journal of Drug Delivery and Therapeutics - Year 2017, Vol 7, Issue 7
Abstract
Indene N-oxide derivatives were used for docking and three dimensional quantitative structure activity relationship studies. Molecular docking and validation studies were carried out for all compounds on peroxisome proliferator activated receptor γ active site. The reliability of the docking results was acceptable with good root mean square deviation value (ranging from 0.96 to 2Å). The three dimensional quantitative structure activity relationship studies were also carried out by advanced technique (Stepwise forward-backward variable selection method) using training set of 19 compounds and test set of 7 compounds. A statistically reliable model with good predictive power (q2 = 0.8820, Pred r2= 0.7063) was achieved. Both above approaches illustrated insights into the structure activity relationship of these compounds which may helps in the design and development of potent indene N-oxide derivatives as PPARγ agonists.
Authors and Affiliations
Ganesh Prasad Mishra
Keywords
Related Articles
- EP ID EP300619
- DOI -
- Views 77
- Downloads 0
THE PREVALENCE OF INDIAN COMMON KRAIT ENVENOMATION AND ITS CLINICAL COMPLICATIONS AMONG THE RURAL POPULATIONS OF INDIA
Snake envenomations have been a serious yet often overlooked public health threat especially in tropical and subtropical countries, including Southeast Asia. The medically important venomous land snakes in Southeast Asia...
AWARENESS, RISK PERCEPTION AND PRACTICE OF SELF-MEDICATION AMONG PREGNANT WOMEN ATTENDING ANTE-NATAL CLINICS IN SOKOTO, NIGERIA
Background: In addition to its adverse health effects on mother and fetus, self-medication is believed to be one of the main driving forces behind the increasing burden of antimicrobial resistance worldwide. This study a...
EMPATHY AND SYMPATHY AMONG MEDICAL STUDENTS: CHANGING TRENDS
Objectives: There is general belief that empathy is crucial for the physician-patient relationship and thus an important issue in medical education. This comparative study was designed to establish the changing attitude...
EFFECT OF NIMODIPINE AND DICLOFENAC IN EXPERIMENTALLY INDUCED CONVULSIONS USING INH AND ELECTRO CONVULSOMETER IN RATS AND MICE
Aim: The study aims to evaluate the anticonvulsant effect of Nimodipine and combined effect of Nimodipine and Diclofenac in experimentally induced seizures in Rats and Mice taking distilled water as control. Material an...
PHARMACOLOGICAL ASSESSMENT OF ANTIDIABETIC POTENTIAL OF HYDROALCOHOLIC EXTRACT OF CASSIA FISTULA LINN. IN STREPTOZOTOCIN-INDUCED DIABETIC RATS
Major public health problem “diabetes” is approaching epidemic proportions globally and increasing at alarming rate all over the world. The Medicinal plants of India plays important role in the management of diabetes as...