QTc Interval and Oxidative Stress Markers Variation in Acute Myocardial Infarction
Journal Title: Scholars Journal of Applied Medical Sciences - Year 2017, Vol 5, Issue 12
Abstract
Abstract: Stress is common in day-to-day life and it affects many physiological functions of the body, mainly the cardiovascular system, may precipitate acute myocardial infarction (AMI), ventricular tachycardia and ventricular fibrillation. The present study was carried out to evaluate carbonyl stress (protein carbonyl), lipid profile and malondialdehyde (MDA) levels in AMI patients compared with healthy controls. Protein carbonyl is commonly used biomarker of oxidative stress; it is irreversible modification that develops when reactive aldehydes or ketones are added to amino acid residues. Samples were collected from 25 Acute myocardial infarction patients, 25healthy age and sex matched subjects were selected as control. The ECG results were evaluated for different parameters like heart rate, QRS complex, QTc intervals. Biochemical analysis like Lipid Profile, Protein carbonyl assay and serum MDA were done by using different standard methods Heart rate, SBP and DBP was more in AMI patients. Mean values of triglycerides levels, LDL Cholesterol levels were increased and HDL Cholesterol levels were decreased in the study group. There was statistically significant increase in malondialdehyde concentration and Carbonyl protein levels in AMI. To conclude increased QTc interval, elevated MDA and carbonyl protein in serum along with lipid profile are essential diagnostic tools for AMI. An elevated protein carbonyl (PC) level appears for a long period when compared with other parameters. Measuring protein carbonyl levels as biomarkers of oxidative stress has some advantages in comparison with the measurement of other oxidation products because of relative early formation and relative stability of carbonylated proteins. Keywords:Acute myocardial infarction (AMI), Malondialdehyde (MDA), Reactive Oxygen Species (ROS).
Authors and Affiliations
Omkar NG, Santhosh Kumar, BaluMahendran K
Keywords
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