Quantification Assay of Methoxsalen from Bulk Dosage Form by UV-Spectrometry Method
Journal Title: Scholars Academic Journal of Pharmacy - Year 2016, Vol 5, Issue 4
Abstract
Rapid, specific and economic UV spectrophotometric method has been developed to determine the methoxsalen content in bulk and pharmaceutical dosage formulations. At a pre-determined λ max of 247nm,it was proved linear in the range of 1.0–12.0 mg/mL, and exhibited good correlation coefficient (R2-0.999 .This method was successfully applied to the determination of methoxsalen content in marketed brand(MelanocylR2-0.982, MeladermR2-0.971) and the results were in good agreement with the label claims. Methoxsalen is a photosensitizing agent which has a chemical structure susceptible to degradation. The obtained results proved that the method can be employed for the routine analysis of methoxsalen in bulks as well as in the commercial formulations. Keywords:Methoxsalen, UV-Spectrscopy, and Marketed preparation.
Authors and Affiliations
Manisha B. Parhad
Keywords
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