QUANTITATIVE DETERMINATION OF SILDENAFIL CITRATE IN COMMERCIAL TABLET DOSAGE FORM MARKETED IN MAIDUGURI METROPOLITAN COUNCIL (MMC)
Journal Title: International Research Journal of Pharmacy (IRJP) - Year 2012, Vol 3, Issue 9
Abstract
A quantitative analysis was carried out to determine the claimed content of sildenafil citrate present in commercial tablet dosage forms of different brands, using the reference standard from the developed method for assay of sildenafil citrate. Nine different samples were analysed using HPLC and UV- Spectrophotometric method. For the HPLC and UV Spectrophotometer result, Pramo V has a percentage content of 103.7% and 102.6%, power 97.5 and 96.5% Man- up 95.2% and 96.9%, soga 104.2% and 104.6, caverta 101.9% and 100.2%, Homograe 102.8% and 100.5% , Teagra 99.0% and 98.4%, vega 91.3% and 91.4% and ceagra 109.1% and 114.4% , respectively. It was observed that both vega and ceagra samples has a percentage concentration of 91.3, 91.4% and 109.1% , 114.4% respectively. They thus failed the analysis test as the percentage content did not fall within the standard range of 95%-105% Based on the result obtained, about 78% of drugs that contain sildenafil citrate passed the analysis, while 22% failed.
Authors and Affiliations
Ali Sani , Ogunbameru Wole , Musa Sani, Ojuolape Rafat , Abdulraheem Ramat
Keywords
Related Articles
- EP ID EP103559
- DOI -
- Views 70
- Downloads 0
DEVELOPMENT OF FIRST ORDER DERIVATIVE ULTRAVIOLET SPECTROPHOTOMETRIC METHOD FOR SIMULTANEOUS ESTIMATION OF LEVOCETIRIZINE HYDROCHLORIDE AND PHENYLEPHRINE HYDROCHLORIDE IN BULK AND COMBINED DOSAGE FORM
The first order derivative method of ultraviolet spectrometry for simultaneous determination of Levocetirizine hydrochloride (LEV) and Phenylephrine hydrochloride (PHE) in bulk drug and combined dosage form was found to...
AN OVERVIEW OF GASTRORETENTIVE DRUG DELIVERY SYSTEM RESEARCH
The reason of writing this research article on gastro retentive drug delivery systems was to gather the recent literature with special focus on various gastro retentive approaches that have recently become leading method...
STUDY OF THE ANTIHYPERLIPIDEMIC, ANTIOXIDATIVE AND ANTIATHEROGENIC ACTIVITY OF TRITICUM AESTIVUM LINN. IN RABBIT RECEIVING HIGH FAT DIET
The aim was to study of the antihyperlipidemic, antioxidative and antiatherogenic activity of Triticum aestivum Linn. in rabbit receiving high fat diet. Twenty rabbits of either sex were taken and divided into four group...
COMPOSITION OF THE VOLATILE OIL OF ZINGIBER OFFICINALE ROSCOE RHIZOMES AND EFFECTS OF PHYSICAL FACTORS ON THE OIL
The chemical composition of the volatile oil of ginger, Zingiber officinale Roscoe (Zingiberaceae) rhizomes of Delhi region, has been studied under different physical factors. The volatile oil of the fresh rhizomes is co...
KNOWLEDGE, ATTITUDE AND PERCEPTION TOWARDS JAUNDICE AMONG AYDER REFERAL HOSPITAL HEALTH WORKERS
The objective of the study was to determine knowledge, practice and attitude towards jaundice among hospital health workers in Ayder Referral Hospital. Jaundice is a condition in which a person's skin and the whites of t...