Quantitative NS1 antigen and the severity of dengue virus infections
Journal Title: Paediatrica Indonesiana - Year 2015, Vol 55, Issue 2
Abstract
Background Dengue infection is one of the main cause ofmorbidity and mortality in children in Indonesia. Since it is knownthat earlier treatment and supportive therapies can decreased casefatality rate from dengue hemorrhagic fever (DHF), identificationof children who have risks to develop to DHF must be quicklyidentified, mainly in areas of endemic.Objective To find a correlation between increased quantitativesecreted nonstructural protein-1 (sNS1) with clinical course ofsevere dengue infections.Methods This was a cross-sectional study conducted on childrenwith dengue infections in Tropical Infections Division of ChildHealth Department, Sanglah Hospital, Denpasar. Detection ofthe dengue antigen was made by examining sNS1 quantitativeimmuno-assay. Analysis correlation of Spearman test was used tolook the relationship between increased quantitative sNS1 withclinical course of severe dengue infections.Results There was a positive relationship between quantitativesNS1 and clinical course of severe dengue infections with a valueof r = 0.903, P=0.001. Increased sNS1 level had a positivecorrelation with more severe dengue infections.Conclusions Quantitative sNS1 titer has a strong positivecorrelation with clinical course of severe dengue infections.
Authors and Affiliations
Ni Made Adi Purnami, Mohammad Juffrie, Made Gde Dwi Lingga Utama
Keywords
Related Articles
- EP ID EP448530
- DOI 10.14238/pi55.2.2015.87-90
- Views 99
- Downloads 0
Glycated hemoglobin HbA1c, waist circumference, and waist-to-height ratio in overweight and obese adolescents
Background Central obesity has been associated with a high risk of insulin resistance. Waist circumference and waist-to-height ratio are anthropometric indices for determining central obesity and have been associated wit...
Third trimester maternal 1,25-dihydroxyvitamin D and neonatal birth weight
AbstractBackground The main cause of neonatal mortality is low birth weight. Active form of vitamin D (1,25-dihydroxyvitamin D) increase the efficiency of calcium and phosphorous absorption in intestinal. Deficiency 1,25...
Outcomes of acute kidney injury in children at Muhammad Husin Hospital, Palembang
Background Acute kidney injury (AKI) is a common problemin hospitalized pediatric patients, with effects on morbidity andmortality.Objectives To assess for the incidence and common etiologies ofAKI, as well as to review...
Thyroid hormone profile and PELOD score in children with sepsis
Background Thyroid hormonal dysfunction, also known aseuthyroid sick syndrome or nonthyroidal illness, can be seenin sepsis. There have been few studies on thyroid hormonedysfunction in septic children, as well as on a r...
Albendazole alone vs. albendazole and diethylcarbamazine combination therapy for trichuriasis
Background Trichuris trichiura is one of the most commonsoil-transmitted helminths, estimated to infect l billion peopleworldwide. Several studies have compared the efficacies ofalbendazole and diethylcarbamazine, but th...