Radiotherapy in Post Mastectomy High Risk Breast Cancer: Early results of a Prospective Study comparing Conventional versus Hypofractionated Radiotherapy
Journal Title: Journal of Medical Science And clinical Research - Year 2018, Vol 6, Issue 7
Abstract
Purpose: Role of adjuvant radiotherapy postmastectomy in improving local-regional control and overall survival is well established. Conventional radiotherapy delivers 50-60 Gray (Gy) in 5-6 weeks time and often women find it difficult to comply with this treatment. A shorter duration hypofractionated treatment, if found to be safe and effective, will be more convenient for patients and treatment providers alike and hence the need for this prospective study Materials & Methods: Fifty breast cancer patients who underwent mastectomy were enrolled and randomized into the study arms- Conventional Arm (CF) [50Gy in 25 Fractions] and Hypofractionation arm (HF) [40Gy in 15 Fractions]. Treatment related acute toxicities and compliance to treatment were recorded and compared between the arms using appropriate statistical tools. Results: Both arm enrolled 25 patients each and their baseline characters were found well matched. Incidence of Grade2 and 3 acute skin toxicities was higher in the CF arm (28% and 8%, respectively) as compared to HF arm (16% and 0%, respectively). Grade 1 Odynophagia was also higher in CF arm (68% vs 52%). The difference in toxicities was not statistically significant (p-value >0.05). With regards to treatment duration, a mean delay of 1.8 days in HF arm versus 4.76 days in CF arm was observed (pvalue 0.0009), implying that the shorter duration HF arm had significantly less interruptions in treatment completion. Conclusion: In postmastectomy setting, hypofractionated radiotherapy showed lesser acute toxicities, was better in terms of treatment compliance and hence can be used routinely.
Authors and Affiliations
Partha Pratim Medhi, MD (Radiotherapy)
Keywords
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