Randomised Clinical Trial to Compare the Sedative Effects of Oral Triclofos with Oral Midazolam as Premedicants in Children
Journal Title: IOSR Journal of Dental and Medical Sciences (IOSR-JDMS) - Year 2019, Vol 18, Issue 3
Abstract
Background and Aims: Premedication in children is necessary to allay fear and anxiety before surgery and provide a smoother anaesthesia for the children. The search for a perfect premedicant has been on and continues. So we have done this study to find out a good premedication out of the ones widely used. Oral midazolam and Oral triclofos were compared as a premedicant in paediatric patients coming for daycare surgeries in our study. Methods: Double blinded randomised clinical trial was conducted.150 children of ASA class 1 were randomly allocated into 2 groups, one group received oral midazolam 0.5 mg/kg body weight and the other group received oral triclofos 75mg/kg body weight. Drug acceptance score, parent separation score and mask acceptance score were compared among the two groups. Sedation scores were recorded at various time intervals and after 45 minutes of drug administration in both the groups. Also the hemodynamic variables and adverse effects were recorded in both the groups. The collected data was analysed with SPSS 16.0 version. To find the significance difference between the bivariate samples in paired groups Wilcoxon signed rank test was used for skewed data and paired sample t-test for the normal data and for independent groups MannWhitney U test for skewed data and unpaired sample t-test for the normal data was used. For the multivariate analysis in the repeated measures the Friedman test was used. The probability value 0.05 is considered as significant level. Results: Triclofos being more palatable, was better accepted by the children, produced excellent sedation than midazolam after 45 minutes. The parent separation score was comparable between the two groups. The mask acceptance score was good with triclofos than midazolam. The postoperative recovery score was better with triclofos. Conclusion: Oral triclofos is better than oral midazolam as a sedative premedicant in paediatric patients.
Authors and Affiliations
Dr Mytily, Dr. Sathya
Keywords
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- EP ID EP556720
- DOI 10.9790/0853-1803113741.
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