Raphanus sativus ameliorates atherogeneic lipid profiles in hypercholesterolemic rats and hypercholesterolemia-associated peroxidative liver damage
Journal Title: JOURNAL OF ADVANCES IN CHEMISTRY - Year 2014, Vol 7, Issue 3
Abstract
Objective: Raphanus sativus is a hugely used edible root vegetable. We investigated whether the feeding of the Raphanus sativus hot water extract (RSE) ameliorates atherogenic lipid profile and oxidative stress in hypercholesterolemia. Methods: After feeding of the RSE to hypercholesterolemic rats for 6 weeks, the levels of plasma and hepatic total cholesterol (TC), triglyceride (TG), and plasma high density lipoprotein-cholesterol (HDL-C) and fecal TC levels were studied. The effects of RSE on the hepatic enzymes, namely alanine aminotransferase (ALT), aspartate aminotransferase (AST) and alkaline phosphatase (ALP), the levels of lipid peroxide (LPO) and liver histology were also evaluated. Results: Hypercholesterolemia increased the levels of TC and TG in the plasma and livers. The levels of ALT, AST and ALP in plasma and LPO in the liver also increased. The dietary RSE, however, significantly ameliorated the above atherogenic lipids and liver enzymes. The RSE significantly reduced the levels of LPO in the liver, suggesting an in vivo protection against of oxidative stress. The RSE also inhibited the in vitro Fenton’s reagent-induced oxidative stress, thus corroborating the in vivo anti-LPO actions of RSE. The levels of hepatic LPO were positively correlated with plasma AST (r=0.76; P <0.05) and ALT (r=0.43; P<0.05) levels. Histologically, the livers of the RSE-fed hypercholesterolemic rats exhibited lesser fatty droplets and reduced inflammatory cells. Conclusion: Finally, R. sativus extract lowers the cardiovascular disease risk factors under hypercholesterolemic situation by increasing the plasma/hepatic clearance of cholesterol and improving the hypercholesterolemia-induced oxidative damage of hepatic tissues.
Authors and Affiliations
Mozammel Haque, Jahirul Islam, Asiqur Rahaman, Fowzia Akter Selina, Mohammad Azizur Rahman, Mahmudul Hasan, Shahdat Hossain
Keywords
Related Articles
- EP ID EP652643
- DOI 10.24297/jac.v7i3.2374
- Views 153
- Downloads 0
Validation of multi-machine and single-machine equivalent models for wind farm transient stability studies
Stability study of power system with wind farm is challenging task due to collection of system data, computation burden in case of system order and long simulation time. An aggregated representation of fixed speed wind t...
THE CONVERSION OF N – METHYLANILINE AND N –, 2 – DIMETHYLANILINE BY USING DIFFERENT CATALYSTS
The catalytic conversion of N methylaniline and N, 2 dimethylaniline in the presence of Pd HSHM, CuFe2O4·γ·Al2O3 and vanadium chromium aluminium (VChA) oxide systems has been investigated. The comparative analys...
Azo-Hydrazone Tautomerism and Antimicrobial activity of New substituted Imidazolines and Perimidines
Two new series of 2-{1-[(substitutedphenyl)-hydrazono]-2-oxo-2-phenyl-ethyl}-5,5-diphenyl-3,5-dihydro-imidazol-4-one  and (1H-Perimidin-2-yl)-[(substitutedphenyl)-hydrazono]-acetic acid ethyl ester were prepared by co...
Synthesis and Physico-Chemical Characterization of a New Non-Centrosymmetric Organic Cation Iodate
The synthesis, crystal structure and physico-chemical characterization are presented for the piperazinium bis iodate dihydrate. An X-ray investigation has shown that this compound crystallizes in a non-centrosymmetric mo...
RECYCLED POLYETHYLENE BONDED PARTICLE BOARD FROM PULPED AND UNPULPED GMELINA ARBOREA SAW DUST WASTES
Particle boards were prepared from saw dust wastes obtained from Gmelina aborea using polyethylene as binder. The boards were produced under three different compositional variables, namely: particles sizes (1 µm, 1.5 µ...