RATIONAL USE OF ANTIBIOTICS IN OSTEOMYELITIS
Journal Title: Journal of Pharmaceutical Sciences and Research - Year 2010, Vol 2, Issue 11
Abstract
Osteomyelitis (OM) is a progressive infection of the bone marrow and cortex caused by bacteria or fungi resulting in inflammatory destruction of the bone. The incidence of disease is related to joint replacements, complex surgical interventions and wound infections. Aim was to evaluate the rational use of antibiotics to reduce the further incidence of infection & mortality related to OM.This was a retrospective study carried out in different hospitals of Lahore. A total of 35 patients with the complaint of Osteomyelitis were selected randomly from the Jinnah Hospital, Lahore; Mayo Hospital, Lahore between the period of 7th June 2010 to 28th June 2010.Study method adopted was performa. Through our study we came to know that males are more commonly affected than females. 57.14% patients have compromised health status because host deficiencies are involved in the direct inoculation of micro-organism & spread of infection. Most commonly affected bone by OM is Tibia(51.4%) and Femur(34.28%). S.aureus was most common causative agent of OM in 78.26% of patients.Most commonly prescribed antibiotics for OM are Cephalosporins 57.14%, Fusidic acid and Linezolid 34.28%, Other Penicillins & Fluoroquinolones 20%. We concluded that rational antimicrobial treatment often involves a combination of antibiotics, either given orally or parentally based on results regarding microorganism sensitivity, patient compliance & health status of patients. A minimum of 4-6 weeks of oral or parenteral antimicrobial therapy along with surgery has become a standard therapy for Osteomyelitis.
Authors and Affiliations
Khawaja Tahir Mahmood , Maryam Nadeem , Sundas Nadeem , Fatima Amin
Keywords
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