Rational use of antibiotics in preterm neonates

Journal Title: Medpulse International Journal of Pediatrics - Year 2017, Vol 4, Issue 3


Objectives: 1) To manage low infection risk preterms without antibiotics and determine their outcome. 2) To find out relation between maternal risk factors, gestational age and birth weight with regard to need for antibiotics Materials and Methods: Setting: NICU, BVDUMC and H, Sangli Study Design: Prospective Analytical Study. Study Period: 8 months Methods: Inborn Preterm babies with low risk factors for infection were closely monitored without antibiotics. Babies were started on antibiotics only when sepsis was considered. Detailed maternal history with regard to obstetric risk factors was recorded. Gestational age and birth weight were correlated with need for antibiotics. Babies were followed up till discharge or death. Results: Of 296 babies admitted in NICU during study period, 74 eligible preterms were enrolled. Sixty two (83%) out of 74 did not require antibiotics. There was statistically significant difference in mean birthweight (1.765+0.37kgs) between neonates who required antibiotics and those who did not. (p-value<0.001). There was no significant association of gestational age with need for antibiotics. Maternal obstetric risk factors had significant association with need for antibioticsin the babies (p-value= 0.025). Three babies (4%) who received antibiotics developed NEC as against none in the non-antibiotics group. Only 2(16.3%) out of the 12 babies in antibiotic group had positive blood cultures. Mortality was 4.1% Conclusion: Preterms with low risk factors can be managed without antibiotics. Need for antibiotics is strongly associated with maternal obstetric risk factors and low birth weight.

Authors and Affiliations

Harshal Wagh, Amit Tagare, Sara Dhanawade


Related Articles

A study of therapeutic role of upper GI endoscopy at tertiary health care centre

Background: As the child grows, explores and interacts with their local habitat they inevitably put foreign bodies into their mouths, ingesting a small proportion of them. Of over a 100000 cases of foreign body ingestion...

Maternal factors as determinants of low birth weight deliveries

Background: Maternal factors are more influential in affecting neonatal birth weight through biological and non-biological means. Some of the bio-social factors like maternal age, parity, height, weight, gestation, etc.,...

Screening the new born for hearing loss - An experience at tertiary care hospital

Background:If the hearing loss in newborn is identified at a very early period of life before plasticity sets in, proper rehabilitation can be done so that child will have a good and prosperous adult life.The screening s...

Study of congenital malformations and related maternal and foetal factors: Hospital based study

Background: Congenital malformation represents defects in morphogenesis during early fetal life. According to the World Health Organization (WHO) document of 1972. Aims and Objectives: To Study of Congenital Malformation...

Clinical Profile and Etiology of Adolescent Epilepsy: A Study at Tertiary Care Hospital

Background: Epilepsy is the most common neurological disorder of adolescence. The clinical profile, etiology and clinical pattern, varies with age dependent fashion and adolescent epilepsy differs sharply from others. Ai...

Download PDF file
  • EP ID EP260294
  • DOI -
  • Views 119
  • Downloads 0

How To Cite

Harshal Wagh, Amit Tagare, Sara Dhanawade (2017). Rational use of antibiotics in preterm neonates. Medpulse International Journal of Pediatrics, 4(3), 62-65. https://europub.co.uk/articles/-A-260294