Reticulocytosis and direct coombs test as markers of haemolysis in neonatal hyperbilirubinemia requiring phototherapy

Journal Title: Medpulse International Journal of Pediatrics - Year 2018, Vol 6, Issue 2

Abstract

Background: Neonatal hyperbilirubinemia is seen in 60% full-term neonates in first week of life. Among these8-11 % require phototherapy. Causes of hyperbilirubinemia can be immune or non-immune causes. Reticulocytosis and Direct Coombs test positivity can be markers for haemolytic hyperbilirubinemia. Objective: To identify the incidence of reticulocytosis in immune and non-immune mediated haemolyticjaundice, to note whether thereis any significant difference in reticulocytosis between the two groups and to identify the association if any between reticulocytosis and Direct Coombs test. Methods: Aprospective study was done in a teaching institution including 100 term neonates requiring phototherapy. They were categorized into three groups as possible immune haemolytic(divided into Rh and ABO incompatibility) and possible non immune cause as per the maternal and baby blood groups. Reticulocyte count and Coombs test were done on starting phototherapy. Statistical analysis was done with SPSS version 20.0. Descriptive statistics, Chi-square test and Fisher’s exact test were used for analysis. Results: Rh incompatibility group showed 100% positivity for both reticulocytosis and Direct Coombs test. In ABO incompatibility group reticulocytosis was 56.5% and Coombs positivity was 84.6%. 5% of those babies with Noincompatibility had reticulocytosis. Direct Coombs test was positive in 7.4% of babies in this group. There was a significant association between haemolytic cause of hyperbilirubinemia and reticulocytosis .No association seen between reticulocytosis and Coombs test positivity in ABO incompatibilitynor in No incompatibility group. Conclusion: Reticulocytosis, Coombs positivity are good markers to identify haemolysisas the major cause of hyperbilirubinemia

Authors and Affiliations

Rugmini Kamalammal, Sanjay K Masaradd, K E Elizabeth

Keywords

Related Articles

Role of serum zinc levels in simple febrile convulsions in children

Background: Febrile convulsions in children can be induced by several factors. In febrile convulsions there is an enhanced neuronal excitability during the normal brain maturation. Gamma amino butyric acid is an importan...

A study of incidence of neonatal jaundice in newborns at a tertiary health care centre

Background: Hyperbilirubinemia in neonates is a primary concern due to it’s long term neurological effects on neonates.Aim and objective: To study the incidence of neonatal jaundice in new born at a tertiary health care...

Early onset neonatal sepsis in relation to prolonged rupture of membranes of more than 18 hours - A prospective study

Background: Sepsis is the commonest cause of neonatal mortality globally and is responsible for about 3–50% of the total neonatal deaths in the developing countries. In India, sepsis contributes up to 52% of neonatal dea...

Early onset neonatal sepsis in relation to prolonged rupture of membranes of more than 18 hours - A prospective study

Background: Sepsis is the commonest cause of neonatal mortality globally and is responsible for about 3–50% of the total neonatal deaths in the developing countries. In India, sepsis contributes up to 52% of neonatal dea...

Prevalence of overweight and obesity among peri-pubertal children of rural school in India

Background: Overweight and obesity in children have become a public health problem worldwide. This poses a high risk for adult obesity. The prevention of obesity onset should include preventative policies and measures ag...

Download PDF file
  • EP ID EP360123
  • DOI -
  • Views 115
  • Downloads 0

How To Cite

Rugmini Kamalammal, Sanjay K Masaradd, K E Elizabeth (2018). Reticulocytosis and direct coombs test as markers of haemolysis in neonatal hyperbilirubinemia requiring phototherapy. Medpulse International Journal of Pediatrics, 6(2), 27-30. https://europub.co.uk/articles/-A-360123