Role of serum zinc levels in simple febrile convulsions in children
Journal Title: Medpulse International Journal of Pediatrics - Year 2019, Vol 9, Issue 1
Abstract
Background: Febrile convulsions in children can be induced by several factors. In febrile convulsions there is an enhanced neuronal excitability during the normal brain maturation. Gamma amino butyric acid is an important inhibitory neurotransmitter. Zinc has a regulatory effect on glutamic acid decarboxylase and the synthesis of GABA. Aim: To determine whether children with simple febrile convulsion had low serum zinc levels compared to children with fever alone. Material and Methods: In this prospective observational study a total of 100 children were divided in case and control groups, i.e., children with simple febrile convulsions (case group=50 children) and febrile children without convulsions (control group=50 children). Serum zinc was done by calorimetric method. Results: The mean serum zinc levels in the present study in simple febrile convulsions and in fever alone without convulsions were 50.44 g/dl and 59.5 g/dl respectively. Mean Zinc levels were significantly less in children with simple febrile convulsions. Conclusion: The serum zinc levels were decreased in children with simple febrile convulsions when compared to children with fever alone without convulsions, thus indicating that zinc deprivation plays significant role in the pathogenesis of febrile convulsions.
Authors and Affiliations
S W Srikanth, Sharanagouda Patil, Rachapudi Venkata Anusha
Keywords
Related Articles
- EP ID EP469564
- DOI 10.26611/10149111
- Views 158
- Downloads 0
Effect of type of anaesthesiain lower segment caesarean section on apgar score of newborn babies: A comparative study
Background: To compare the effects of general anaesthesia and spinal anaesthesia on Apgar score in full term neonates born to elective caesarean section.Methods: The study was conducted on 90 healthy fullterm patients of...
Study of hematological and coagulation profile of term neonates born to mothers with PIH as compared to term neonates born to normotensive mothers
Objectives: To study the changes in Hematological and Coagulation profile of newborns born to mothers with hypertensive disorders of pregnancy and in neonates born to normotensive mothers. Methods: A prospective study to...
A study efficacy of pyridoxine in early-onset idiopathic intractable seizures in pediatric patient at tertiary health care center
Background: Pyridoxine is used for management of seizure disorder in three settings viz., seizures that respond to pyridoxine and require life-long supplementation with therapeutic doses of pyridoxine, pyridoxine depende...
Serum glucose levels in preterm neonates during the first 72 hours of life
Background: Postnatal hypoglycemia is common in preterm neonates. The assessment of blood glucose has become an inherentpart of basic neonatal care in many centres. Aim: To provide useful data for the prevention and trea...
Effect of long-term treatment with an inhaled corticosteroid (budesonide) on airway hyper responsiveness and clinical asthma in nonsteroiddependent asthma in children
Several short-term studies have shown that inhaled steroids can reduce airway hyper responsive in asthma. To evaluate whether prolonged treatment can bring about full recovery, this double blind, randomized, control tria...