RECENT ADVANCE OF NANOTECHNOLOGY FOR THE TREATMENT OF OCULAR DISEASE
Journal Title: World Journal of Pharmaceutical Research - Year 2018, Vol 7, Issue 8
Abstract
Nanoformulation are use as an alternative for traditional ophthalmic formulation. Their are various factors that creats problem in treatment of ocular disease like rapid elimination, enzymatic drug degradation, Protein binding and physiological barrier etc. All these factors cause reduction in intraocular residence time and poor bioavailability. Recent research study shows that nanoformulation can enhance the therapeutic efficacy and bioavailability of ocular drugs compared to conventional ocular formulation. The various research study in number of patent shows significant increase in therapeutic efficacy for various chronic disease states of both anterior and posterior ocular segments. The nanoformulation approach enhance the ocular bioavailability by reducing the drug protein binding, increasing the corneal resident time, enhancing the drug permeability and also providing a sustained drug release. United States Food and Drug Administration (USFDA) has approved ocular drugs employing nanotechnology and future developments.
Authors and Affiliations
Geetanjali Khanna
Keywords
Related Articles
- EP ID EP626825
- DOI -
- Views 135
- Downloads 0
ICSI OUTCOME AFTER USE OF DURIAN FOR INFERTILE MALE
Background: In vitro fertilization (IVF) cycle outcome correlates with the severity of seminal fluid analysis abnormalities as well as maternal age, number of follicles picked up and endometrial condition at time of embr...
DESIGN OF A VALIDATION OF CAUDAL ANALGESIMETRY IN EXPERIMENTAL PHARMACOLOGY
Caudal analgesia is one of the most used tests in recent years to evaluate the reflex response to nociceptive stimulation in the animal model. The aim of our work was to study the different parameters involved in the ana...
ANTI- HEMORRHAGIC ACTIVITY OF NATHAICHOORI VIRAI CHOORANAM; A MULTI HERBAL SIDDHA FORMULATION
Siddha medicine is one of the oldest medical systems known to mankind. More than 2500 years ago, the Siddha system of medicine is generated from Dravidian culture. It is claimed to revitalize and rejuvenate dysfunctional...
MAJOR TYPES OF ANAEMIA AMONG THE CHILDREN ATTENDING PAEDIATRIC DEPARTMENT OF UDUTH, SOKOTO, NORTH-WESTERN NIGERIA
The World Health Organization (WHO) defined anaemia as HB <12g/dl in adult non-pregnant female, Hb < 11g/dl in pregnant females, Hb <13g/dl in adult men, Hb <12g/dl and Hb <11g/dl in male & female children respectively....
ASSESSMENT OF IRON PROFILE IN SUDANESE KIDNEY POSTTRANSPLANT PATIENTS -KHARTOUM STATE
Background: Posttransplantation anemia (PTA) is a common obstacle for kidney post-transplant patients and a risk factor for many complicated consequences. Exposure to the immunosuppressive drug has a role on iron profile...